Description: Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. RefSeq Summary (NM_000812): The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr4:47,033,295-47,046,387 Size: 13,093 Total Exon Count: 4 Strand: +
alcohol dependence Parsian A et al. 1999, Human chromosomes 11p15 and 4p12 and alcohol dependence: possible association with the GABRB1 gene., American journal of medical genetics. 1999 Oct;88(5):533-8.
[PubMed 10490712]
Results with TH and DRD4 genes indicate that these two genes may not play major roles in the development of alcoholism.
Body Height Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
Body Height Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK225686 - Homo sapiens mRNA for Gamma-aminobutyric-acid receptor beta-1 subunit precursor variant, clone: SYN05435. BC022449 - Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1, mRNA (cDNA clone MGC:25991 IMAGE:4797401), complete cds. AK225167 - Homo sapiens mRNA for Gamma-aminobutyric-acid receptor beta-1 subunit precursor (GABA(A) receptor) variant, clone: CBR02137. X14767 - Human mRNA for GABA-A receptor, beta 1 subunit. AK312720 - Homo sapiens cDNA, FLJ93124, highly similar to Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. AK293691 - Homo sapiens cDNA FLJ57719 complete cds, highly similar to Gamma-aminobutyric-acid receptor beta-1 subunit precursor. AB385048 - Synthetic construct DNA, clone: pF1KB5121, Homo sapiens GABRB1 gene for gamma-aminobutyric-acid receptor subunit beta-1 precursor, complete cds, without stop codon, in Flexi system. KJ534841 - Homo sapiens clone GABRB1_iso-A_adult-A03 gamma-aminobutyric acid A receptor beta 1 isoform A (GABRB1) mRNA, partial cds, alternatively spliced. KJ535054 - Homo sapiens clone GABRB1_iso-B_fetal-F13 gamma-aminobutyric acid A receptor beta 1 isoform B (GABRB1) mRNA, complete cds, alternatively spliced. DQ892357 - Synthetic construct clone IMAGE:100004987; FLH185502.01X; RZPDo839B11148D gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1) gene, encodes complete protein. DQ893370 - Synthetic construct clone IMAGE:100006000; FLH196710.01X; RZPDo839H02156D gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1) gene, encodes complete protein. DQ895564 - Synthetic construct Homo sapiens clone IMAGE:100010024; FLH185498.01L; RZPDo839B11147D gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1) gene, encodes complete protein. DQ896690 - Synthetic construct Homo sapiens clone IMAGE:100011150; FLH263663.01L; RZPDo839H01155D gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1) gene, encodes complete protein. DQ896691 - Synthetic construct Homo sapiens clone IMAGE:100011151; FLH196706.01L; RZPDo839H02155D gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1) gene, encodes complete protein. CU692622 - Synthetic construct Homo sapiens gateway clone IMAGE:100019567 5' read GABRB1 mRNA. AK296023 - Homo sapiens cDNA FLJ60591 complete cds, moderately similar to Gamma-aminobutyric-acid receptor beta-1 subunit precursor. AK307120 - Homo sapiens cDNA, FLJ97068.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04080 - Neuroactive ligand-receptor interaction