Human Gene RCHY1 (uc010iiq.3)
  Description: Homo sapiens ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase (RCHY1), transcript variant 5, non-coding RNA.
RefSeq Summary (NR_037914): The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013].
Transcript (Including UTRs)
   Position: hg19 chr4:76,404,247-76,439,640 Size: 35,394 Total Exon Count: 9 Strand: -


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:76,404,247-76,439,640)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerH-INVHGNCLynx
MalacardsPubMedTreefamWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RCHY1
CDC HuGE Published Literature: RCHY1
Positive Disease Associations: Arthritis, Rheumatoid
Related Studies:
  1. Arthritis, Rheumatoid
    J Wang et al. The pharmacogenomics journal 2012, Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis., The pharmacogenomics journal. [PubMed 22491018]

-  MalaCards Disease Associations
  MalaCards Gene Search: RCHY1
Diseases sorted by gene-association score: variola minor (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.53 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 282.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  GQ129343 - Synthetic construct Homo sapiens clone HAIB:100068586; DKFZo008D0935 ring finger and CHY zinc finger domain containing 1 protein (RCHY1) gene, complete cds.
LP895498 - Sequence 362 from Patent EP3253886.
AK091501 - Homo sapiens cDNA FLJ34182 fis, clone FCBBF3016928, highly similar to RING finger and CHY zinc finger domain-containing protein 1.
AX747022 - Sequence 547 from Patent EP1308459.
AK308754 - Homo sapiens cDNA, FLJ98795.
AB209072 - Homo sapiens mRNA for RING finger and CHY zinc finger domain containing protein 1 variant protein.
AL050144 - Homo sapiens mRNA; cDNA DKFZp586C1620 (from clone DKFZp586C1620); partial cds.
AF255666 - Homo sapiens CHIMP mRNA, complete cds.
BC015464 - Homo sapiens ring finger and CHY zinc finger domain containing 1, mRNA (cDNA clone IMAGE:3916707), partial cds.
AY888047 - Homo sapiens ring finger and CHY zinc finger domain containing 1 variant 2 (RCHY1) mRNA, complete cds, alternatively spliced.
BC031057 - Homo sapiens ring finger and CHY zinc finger domain containing 1, mRNA (cDNA clone IMAGE:5271225), with apparent retained intron.
BC047393 - Homo sapiens ring finger and CHY zinc finger domain containing 1, mRNA (cDNA clone MGC:48337 IMAGE:5301408), complete cds.
AK308848 - Homo sapiens cDNA, FLJ98889.
AF305424 - Homo sapiens zinc-finger protein mRNA, complete cds.
AK309555 - Homo sapiens cDNA, FLJ99596.
GU937000 - Homo sapiens p53-induced protein with RING-H2 variant D (RCHY1) mRNA, complete cds.
AF247041 - Homo sapiens androgen receptor N-terminal-interacting protein (ARNIP) mRNA, complete cds.
GQ250944 - Homo sapiens p53-induced protein with RING-H2 variant A (RCHY1) mRNA, complete cds, alternatively spliced.
GQ250945 - Homo sapiens p53-induced protein with RING-H2 variant B (RCHY1) mRNA, complete cds, alternatively spliced.
CU690404 - Synthetic construct Homo sapiens gateway clone IMAGE:100020840 5' read RCHY1 mRNA.
GQ129342 - Synthetic construct Homo sapiens clone HAIB:100068683; DKFZo004D0936 ring finger and CHY zinc finger domain containing 1 protein (RCHY1) gene, partial cds.
HQ447979 - Synthetic construct Homo sapiens clone IMAGE:100071345; CCSB010663_01 ring finger and CHY zinc finger domain containing 1 (RCHY1) gene, encodes complete protein.
KJ898567 - Synthetic construct Homo sapiens clone ccsbBroadEn_07961 RCHY1 gene, encodes complete protein.
AB528599 - Synthetic construct DNA, clone: pF1KB3668, Homo sapiens RCHY1 gene for ring finger and CHY zinc finger domain containing 1, without stop codon, in Flexi system.
JF691538 - Homo sapiens cell-line HepG2 PIRH2E (RCHY1) mRNA, complete cds.
JF691539 - Homo sapiens cell-line HepG2 PIRH2F (RCHY1) mRNA, complete cds.
JD535553 - Sequence 516577 from Patent EP1572962.
JD035116 - Sequence 16140 from Patent EP1572962.
JD152351 - Sequence 133375 from Patent EP1572962.
JD463282 - Sequence 444306 from Patent EP1572962.
JD359414 - Sequence 340438 from Patent EP1572962.
JD237379 - Sequence 218403 from Patent EP1572962.
JD349168 - Sequence 330192 from Patent EP1572962.
JD227909 - Sequence 208933 from Patent EP1572962.
JD435804 - Sequence 416828 from Patent EP1572962.
GQ250946 - Homo sapiens p53-induced protein with RING-H2 variant C (RCHY1) mRNA, complete cds, alternatively spliced.
CU689096 - Synthetic construct Homo sapiens gateway clone IMAGE:100022653 5' read RCHY1 mRNA.
KJ902385 - Synthetic construct Homo sapiens clone ccsbBroadEn_11779 RCHY1 gene, encodes complete protein.
JD281537 - Sequence 262561 from Patent EP1572962.
JD496455 - Sequence 477479 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04115 - p53 signaling pathway
hsa04120 - Ubiquitin mediated proteolysis

-  Other Names for This Gene
  Alternate Gene Symbols: NR_037914
UCSC ID: uc010iiq.3
RefSeq Accession: NR_037914

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: NR_037914.1
exon count: 9CDS single in 3' UTR: no RNA size: 4471
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 442.00frame shift in genome: no % Coverage: 99.64
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.