Description: Homo sapiens ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase (RCHY1), transcript variant 5, non-coding RNA. RefSeq Summary (NR_037914): The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]. Transcript (Including UTRs) Position: hg19 chr4:76,404,247-76,439,640 Size: 35,394 Total Exon Count: 9 Strand: -
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RCHY1 CDC HuGE Published Literature: RCHY1 Positive Disease Associations: Arthritis, Rheumatoid Related Studies:
Arthritis, Rheumatoid J Wang et al. The pharmacogenomics journal 2012, Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis., The pharmacogenomics journal.
[PubMed 22491018]
MalaCards Disease Associations
MalaCards Gene Search: RCHY1 Diseases sorted by gene-association score: variola minor (3)
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
GQ129343 - Synthetic construct Homo sapiens clone HAIB:100068586; DKFZo008D0935 ring finger and CHY zinc finger domain containing 1 protein (RCHY1) gene, complete cds. LP895498 - Sequence 362 from Patent EP3253886. AK091501 - Homo sapiens cDNA FLJ34182 fis, clone FCBBF3016928, highly similar to RING finger and CHY zinc finger domain-containing protein 1. AX747022 - Sequence 547 from Patent EP1308459. AK308754 - Homo sapiens cDNA, FLJ98795. AB209072 - Homo sapiens mRNA for RING finger and CHY zinc finger domain containing protein 1 variant protein. AL050144 - Homo sapiens mRNA; cDNA DKFZp586C1620 (from clone DKFZp586C1620); partial cds. AF255666 - Homo sapiens CHIMP mRNA, complete cds. BC015464 - Homo sapiens ring finger and CHY zinc finger domain containing 1, mRNA (cDNA clone IMAGE:3916707), partial cds. AY888047 - Homo sapiens ring finger and CHY zinc finger domain containing 1 variant 2 (RCHY1) mRNA, complete cds, alternatively spliced. BC031057 - Homo sapiens ring finger and CHY zinc finger domain containing 1, mRNA (cDNA clone IMAGE:5271225), with apparent retained intron. BC047393 - Homo sapiens ring finger and CHY zinc finger domain containing 1, mRNA (cDNA clone MGC:48337 IMAGE:5301408), complete cds. AK308848 - Homo sapiens cDNA, FLJ98889. AF305424 - Homo sapiens zinc-finger protein mRNA, complete cds. AK309555 - Homo sapiens cDNA, FLJ99596. GU937000 - Homo sapiens p53-induced protein with RING-H2 variant D (RCHY1) mRNA, complete cds. AF247041 - Homo sapiens androgen receptor N-terminal-interacting protein (ARNIP) mRNA, complete cds. GQ250944 - Homo sapiens p53-induced protein with RING-H2 variant A (RCHY1) mRNA, complete cds, alternatively spliced. GQ250945 - Homo sapiens p53-induced protein with RING-H2 variant B (RCHY1) mRNA, complete cds, alternatively spliced. CU690404 - Synthetic construct Homo sapiens gateway clone IMAGE:100020840 5' read RCHY1 mRNA. GQ129342 - Synthetic construct Homo sapiens clone HAIB:100068683; DKFZo004D0936 ring finger and CHY zinc finger domain containing 1 protein (RCHY1) gene, partial cds. HQ447979 - Synthetic construct Homo sapiens clone IMAGE:100071345; CCSB010663_01 ring finger and CHY zinc finger domain containing 1 (RCHY1) gene, encodes complete protein. KJ898567 - Synthetic construct Homo sapiens clone ccsbBroadEn_07961 RCHY1 gene, encodes complete protein. AB528599 - Synthetic construct DNA, clone: pF1KB3668, Homo sapiens RCHY1 gene for ring finger and CHY zinc finger domain containing 1, without stop codon, in Flexi system. JF691538 - Homo sapiens cell-line HepG2 PIRH2E (RCHY1) mRNA, complete cds. JF691539 - Homo sapiens cell-line HepG2 PIRH2F (RCHY1) mRNA, complete cds. JD535553 - Sequence 516577 from Patent EP1572962. JD035116 - Sequence 16140 from Patent EP1572962. JD152351 - Sequence 133375 from Patent EP1572962. JD463282 - Sequence 444306 from Patent EP1572962. JD359414 - Sequence 340438 from Patent EP1572962. JD237379 - Sequence 218403 from Patent EP1572962. JD349168 - Sequence 330192 from Patent EP1572962. JD227909 - Sequence 208933 from Patent EP1572962. JD435804 - Sequence 416828 from Patent EP1572962. GQ250946 - Homo sapiens p53-induced protein with RING-H2 variant C (RCHY1) mRNA, complete cds, alternatively spliced. CU689096 - Synthetic construct Homo sapiens gateway clone IMAGE:100022653 5' read RCHY1 mRNA. KJ902385 - Synthetic construct Homo sapiens clone ccsbBroadEn_11779 RCHY1 gene, encodes complete protein. JD281537 - Sequence 262561 from Patent EP1572962. JD496455 - Sequence 477479 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04115 - p53 signaling pathway hsa04120 - Ubiquitin mediated proteolysis