Human Gene KLHL2 (uc010ira.3)
Description: Homo sapiens kelch-like family member 2 (KLHL2), transcript variant 3, mRNA.
Transcript (Including UTRs)
Position: hg19 chr4:166,184,349-166,244,308 Size: 59,960 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr4:166,231,707-166,242,477 Size: 10,771 Coding Exon Count: 6
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): KLHL2
CDC HuGE Published Literature: KLHL2
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011705 - BACK
IPR015916 - Gal_Oxidase_b-propeller
IPR006652 - Kelch_1
Pfam Domains: PF01344 - Kelch motif
PF07646 - Kelch motif
PF13415 - Galactose oxidase, central domain
PF13418 - Galactose oxidase, central domain
PF13964 - Kelch motif
SCOP Domains: 63825 - YWTD domain
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
ModBase Predicted Comparative 3D Structure on D3DP30
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Descriptions from all associated GenBank mRNAs
BC022503 - Homo sapiens kelch-like 2, Mayven (Drosophila), mRNA (cDNA clone MGC:26455 IMAGE:4791972), complete cds.BC036468 - Homo sapiens kelch-like 2, Mayven (Drosophila), mRNA (cDNA clone MGC:34014 IMAGE:4799622), complete cds.AF059569 - Homo sapiens actin binding protein MAYVEN mRNA, complete cds.AK315372 - Homo sapiens cDNA, FLJ96418, highly similar to Homo sapiens kelch-like 2, Mayven (Drosophila) (KLHL2), mRNA.DQ893638 - Synthetic construct clone IMAGE:100006268; FLH185732.01X; RZPDo839E05148D kelch-like 2, Mayven (Drosophila) (KLHL2) gene, encodes complete protein.DQ895588 - Synthetic construct Homo sapiens clone IMAGE:100010048; FLH185729.01L; RZPDo839E05147D kelch-like 2, Mayven (Drosophila) (KLHL2) gene, encodes complete protein.CU690356 - Synthetic construct Homo sapiens gateway clone IMAGE:100017421 5' read KLHL2 mRNA.KJ898398 - Synthetic construct Homo sapiens clone ccsbBroadEn_07792 KLHL2 gene, encodes complete protein.AK294103 - Homo sapiens cDNA FLJ60237 complete cds, highly similar to Kelch-like protein 2.BX647776 - Homo sapiens mRNA; cDNA DKFZp686O1959 (from clone DKFZp686O1959).AK025289 - Homo sapiens cDNA: FLJ21636 fis, clone COL08259, highly similar to AF059569 Homo sapiens actin binding protein MAYVEN mRNA.AB209727 - Homo sapiens mRNA for Kelch-like protein 2 variant protein.AK308940 - Homo sapiens cDNA, FLJ98981.AK294336 - Homo sapiens cDNA FLJ60241 complete cds, highly similar to Kelch-like protein 2.JD563722 - Sequence 544746 from Patent EP1572962.JD305321 - Sequence 286345 from Patent EP1572962.JD301408 - Sequence 282432 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: AK308940, D3DP30, D3DP30_HUMAN, hCG_2026099UCSC ID: uc010ira.3RefSeq Accession: NM_001161522
Protein: D3DP30
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AK308940.1
exon count:
11 CDS single in 3' UTR:
no
RNA size:
1765
ORF size:
726 CDS single in intron:
no
Alignment % ID:
99.89
txCdsPredict score:
1221.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.