Description: Homo sapiens kelch-like family member 3 (KLHL3), transcript variant 1, mRNA. RefSeq Summary (NM_001257194): This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]. Transcript (Including UTRs) Position: hg19 chr5:136,972,983-137,071,779 Size: 98,797 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr5:136,972,984-137,071,335 Size: 98,352 Coding Exon Count: 10
ID:D6RH21_HUMAN DESCRIPTION: SubName: Full=Kelch-like protein 3; Flags: Fragment; SIMILARITY: Contains 1 BTB (POZ) domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on D6RH21
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
