Human Gene JAKMIP2 (uc010jgo.2)
  Description: Homo sapiens janus kinase and microtubule interacting protein 2 (JAKMIP2), transcript variant 1, mRNA.
RefSeq Summary (NM_001270941): The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Transcript (Including UTRs)
   Position: hg19 chr5:146,965,004-147,162,411 Size: 197,408 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr5:146,981,324-147,051,369 Size: 70,046 Coding Exon Count: 20 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:146,965,004-147,162,411)mRNA (may differ from genome)Protein (820 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): JAKMIP2
CDC HuGE Published Literature: JAKMIP2

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.85 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 94.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -201.30541-0.372 Picture PostScript Text
3' UTR -1650.826266-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF16034 - JAKMIP CC3 domain

ModBase Predicted Comparative 3D Structure on Q96AA8-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Descriptions from all associated GenBank mRNAs
  AB011127 - Homo sapiens KIAA0555 mRNA for KIAA0555 protein.
AF273057 - Homo sapiens CTCL tumor antigen HD-CL-04 mRNA, complete cds.
AK291280 - Homo sapiens cDNA FLJ75320 complete cds, highly similar to Homo sapiens janus kinase and microtubule interacting protein 2, mRNA.
BC017354 - Homo sapiens janus kinase and microtubule interacting protein 2, mRNA (cDNA clone MGC:29496 IMAGE:5020741), complete cds.
AK299724 - Homo sapiens cDNA FLJ57581 complete cds.
BC003189 - Homo sapiens janus kinase and microtubule interacting protein 2, mRNA (cDNA clone IMAGE:3537913), partial cds.
JD168351 - Sequence 149375 from Patent EP1572962.
JD096086 - Sequence 77110 from Patent EP1572962.
JD268483 - Sequence 249507 from Patent EP1572962.
JD345002 - Sequence 326026 from Patent EP1572962.
JD412994 - Sequence 394018 from Patent EP1572962.
JD347767 - Sequence 328791 from Patent EP1572962.
JD356543 - Sequence 337567 from Patent EP1572962.
JD311651 - Sequence 292675 from Patent EP1572962.
JD330841 - Sequence 311865 from Patent EP1572962.
JD242652 - Sequence 223676 from Patent EP1572962.
JD478669 - Sequence 459693 from Patent EP1572962.
JD353148 - Sequence 334172 from Patent EP1572962.
JD269171 - Sequence 250195 from Patent EP1572962.
JD293563 - Sequence 274587 from Patent EP1572962.
JD428411 - Sequence 409435 from Patent EP1572962.
JD153671 - Sequence 134695 from Patent EP1572962.
JD198622 - Sequence 179646 from Patent EP1572962.
JD272163 - Sequence 253187 from Patent EP1572962.
JD550384 - Sequence 531408 from Patent EP1572962.
JD428408 - Sequence 409432 from Patent EP1572962.
JD334900 - Sequence 315924 from Patent EP1572962.
JD259907 - Sequence 240931 from Patent EP1572962.
JD064703 - Sequence 45727 from Patent EP1572962.
JD310668 - Sequence 291692 from Patent EP1572962.
JD357337 - Sequence 338361 from Patent EP1572962.
JD384955 - Sequence 365979 from Patent EP1572962.
JD146818 - Sequence 127842 from Patent EP1572962.
JD180513 - Sequence 161537 from Patent EP1572962.
JD491304 - Sequence 472328 from Patent EP1572962.
JD177373 - Sequence 158397 from Patent EP1572962.
JD184611 - Sequence 165635 from Patent EP1572962.
JD553989 - Sequence 535013 from Patent EP1572962.
JD513186 - Sequence 494210 from Patent EP1572962.
JD521805 - Sequence 502829 from Patent EP1572962.
JD522664 - Sequence 503688 from Patent EP1572962.
JD553136 - Sequence 534160 from Patent EP1572962.
JD502262 - Sequence 483286 from Patent EP1572962.
JD509936 - Sequence 490960 from Patent EP1572962.
JD501083 - Sequence 482107 from Patent EP1572962.
JD404283 - Sequence 385307 from Patent EP1572962.
KJ892861 - Synthetic construct Homo sapiens clone ccsbBroadEn_02255 JAKMIP2 gene, encodes complete protein.
JD524191 - Sequence 505215 from Patent EP1572962.
EF512550 - Homo sapiens neuroendocrine long coiled-coil protein 1 (NECC1) mRNA, complete cds.
AB385348 - Synthetic construct DNA, clone: pF1KA0555, Homo sapiens JAKMIP2 gene for janus kinase and microtubule-interacting protein 2, complete cds, without stop codon, in Flexi system.
JD338386 - Sequence 319410 from Patent EP1572962.
JD186638 - Sequence 167662 from Patent EP1572962.
JD250868 - Sequence 231892 from Patent EP1572962.
JD212173 - Sequence 193197 from Patent EP1572962.
JD309451 - Sequence 290475 from Patent EP1572962.
CU675960 - Synthetic construct Homo sapiens gateway clone IMAGE:100020427 5' read JAKMIP2 mRNA.
JD085393 - Sequence 66417 from Patent EP1572962.
JD102518 - Sequence 83542 from Patent EP1572962.
JD376482 - Sequence 357506 from Patent EP1572962.
JD278581 - Sequence 259605 from Patent EP1572962.
JD272539 - Sequence 253563 from Patent EP1572962.
JD200354 - Sequence 181378 from Patent EP1572962.
JD479949 - Sequence 460973 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: JAMIP2, KIAA0555, NECC1, NM_001270941, NP_001257870, Q96AA8-3, uc010jgo.1
UCSC ID: uc010jgo.2
RefSeq Accession: NM_001270941
Protein: Q96AA8-3, splice isoform of Q96AA8 CCDS: CCDS59495.1, CCDS4285.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001270941.1
exon count: 22CDS single in 3' UTR: no RNA size: 9272
ORF size: 2463CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4911.50frame shift in genome: no % Coverage: 99.98
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.