Human Gene TRIM26 (uc010jry.3)
  Description: Homo sapiens tripartite motif containing 26 (TRIM26), transcript variant 1, mRNA.
RefSeq Summary (NM_003449): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011].
Transcript (Including UTRs)
   Position: hg19 chr6:30,152,232-30,181,271 Size: 29,040 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr6:30,153,653-30,157,070 Size: 3,418 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:30,152,232-30,181,271)mRNA (may differ from genome)Protein (269 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGeneCardsGeneNetworkH-INVHGNC
LynxMalacardsMGIPubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TRIM26
CDC HuGE Published Literature: TRIM26
Positive Disease Associations: Behcet Syndrome , Lupus Erythematosus, Systemic , Multiple Sclerosis , Schizophrenia
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: TRIM26
Diseases sorted by gene-association score: neural tube defects (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.72 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 690.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -611.511486-0.412 Picture PostScript Text
3' UTR -477.421421-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC021115 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone IMAGE:5094007), with apparent retained intron.
BC032297 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone MGC:40232 IMAGE:4938971), complete cds.
BC024039 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone MGC:12710 IMAGE:3954669), complete cds.
JD079105 - Sequence 60129 from Patent EP1572962.
JD242391 - Sequence 223415 from Patent EP1572962.
JD345828 - Sequence 326852 from Patent EP1572962.
U09825 - Human acid finger protein mRNA, complete cds.
AK122859 - Homo sapiens cDNA FLJ16483 fis, clone BRTHA3002265, highly similar to Human acid finger protein mRNA.
AK096996 - Homo sapiens cDNA FLJ39677 fis, clone SMINT2009973, highly similar to Human acid finger protein mRNA.
JD274816 - Sequence 255840 from Patent EP1572962.
JD281163 - Sequence 262187 from Patent EP1572962.
JD363854 - Sequence 344878 from Patent EP1572962.
JD233352 - Sequence 214376 from Patent EP1572962.
JD428045 - Sequence 409069 from Patent EP1572962.
JD362724 - Sequence 343748 from Patent EP1572962.
JD122869 - Sequence 103893 from Patent EP1572962.
JD415656 - Sequence 396680 from Patent EP1572962.
JD096159 - Sequence 77183 from Patent EP1572962.
JD043040 - Sequence 24064 from Patent EP1572962.
JD496609 - Sequence 477633 from Patent EP1572962.
JD152630 - Sequence 133654 from Patent EP1572962.
JD375884 - Sequence 356908 from Patent EP1572962.
JD267360 - Sequence 248384 from Patent EP1572962.
JD540658 - Sequence 521682 from Patent EP1572962.
JD325044 - Sequence 306068 from Patent EP1572962.
JD164767 - Sequence 145791 from Patent EP1572962.
JD206115 - Sequence 187139 from Patent EP1572962.
JD181311 - Sequence 162335 from Patent EP1572962.
LF341396 - JP 2014500723-A/148899: Polycomb-Associated Non-Coding RNAs.
JD539442 - Sequence 520466 from Patent EP1572962.
JD508696 - Sequence 489720 from Patent EP1572962.
JD325653 - Sequence 306677 from Patent EP1572962.
JD478996 - Sequence 460020 from Patent EP1572962.
JD147881 - Sequence 128905 from Patent EP1572962.
JD439564 - Sequence 420588 from Patent EP1572962.
AK314782 - Homo sapiens cDNA, FLJ95652.
LF341395 - JP 2014500723-A/148898: Polycomb-Associated Non-Coding RNAs.
LF341394 - JP 2014500723-A/148897: Polycomb-Associated Non-Coding RNAs.
LF341393 - JP 2014500723-A/148896: Polycomb-Associated Non-Coding RNAs.
LF341392 - JP 2014500723-A/148895: Polycomb-Associated Non-Coding RNAs.
CU689318 - Synthetic construct Homo sapiens gateway clone IMAGE:100019819 5' read TRIM26 mRNA.
LF341391 - JP 2014500723-A/148894: Polycomb-Associated Non-Coding RNAs.
JD364926 - Sequence 345950 from Patent EP1572962.
JD133366 - Sequence 114390 from Patent EP1572962.
JD322329 - Sequence 303353 from Patent EP1572962.
MA576973 - JP 2018138019-A/148899: Polycomb-Associated Non-Coding RNAs.
MA576972 - JP 2018138019-A/148898: Polycomb-Associated Non-Coding RNAs.
MA576971 - JP 2018138019-A/148897: Polycomb-Associated Non-Coding RNAs.
MA576970 - JP 2018138019-A/148896: Polycomb-Associated Non-Coding RNAs.
MA576969 - JP 2018138019-A/148895: Polycomb-Associated Non-Coding RNAs.
MA576968 - JP 2018138019-A/148894: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK314782
UCSC ID: uc010jry.3
RefSeq Accession: NM_003449

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK314782.1
exon count: 9CDS single in 3' UTR: no RNA size: 2165
ORF size: 810CDS single in intron: no Alignment % ID: 99.72
txCdsPredict score: 1050.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 8
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.