Description: Homo sapiens kinesin family member 6 (KIF6), mRNA. RefSeq Summary (NM_145027): This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]. Transcript (Including UTRs) Position: hg19 chr6:39,302,876-39,693,181 Size: 390,306 Total Exon Count: 22 Strand: - Coding Region Position: hg19 chr6:39,304,308-39,693,086 Size: 388,779 Coding Exon Count: 22
ID:F6VGH2_HUMAN DESCRIPTION: SubName: Full=Kinesin-like protein KIF6; SIMILARITY: Belongs to the kinesin-like protein family. SIMILARITY: Contains 1 kinesin-motor domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Attention Deficit Disorder with Hyperactivity Edmund J S Sonuga-Barke et al. American journal of medical genetics. Part B, Neuropsychiatric genetics 2008, Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetic.
[PubMed 18846501]
Attention deficit hyperactivity disorder symptoms (interaction) Sonuga-Barke ,et al. 2008, Does parental expressed emotion moderate genetic effects in ADHD? an exploration using a genome wide association scan, American journal of medical genetics. Part B, Neuropsychiatric genetics 2008 147B- 8 : 1359-68.
[PubMed 18846501]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on F6VGH2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.