Human Gene KIF6 (uc010jxb.1)
  Description: Homo sapiens kinesin family member 6 (KIF6), mRNA.
RefSeq Summary (NM_145027): This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017].
Transcript (Including UTRs)
   Position: hg19 chr6:39,302,876-39,693,181 Size: 390,306 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr6:39,304,308-39,693,086 Size: 388,779 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:39,302,876-39,693,181)mRNA (may differ from genome)Protein (758 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMalacardsMGI
OMIMPubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F6VGH2_HUMAN
DESCRIPTION: SubName: Full=Kinesin-like protein KIF6;
SIMILARITY: Belongs to the kinesin-like protein family.
SIMILARITY: Contains 1 kinesin-motor domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KIF6
CDC HuGE Published Literature: KIF6
Positive Disease Associations: Attention Deficit Disorder with Hyperactivity , Attention deficit hyperactivity disorder symptoms (interaction)
Related Studies:
  1. Attention Deficit Disorder with Hyperactivity
    Edmund J S Sonuga-Barke et al. American journal of medical genetics. Part B, Neuropsychiatric genetics 2008, Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetic. [PubMed 18846501]
  2. Attention deficit hyperactivity disorder symptoms (interaction)
    Sonuga-Barke ,et al. 2008, Does parental expressed emotion moderate genetic effects in ADHD? an exploration using a genome wide association scan, American journal of medical genetics. Part B, Neuropsychiatric genetics 2008 147B- 8 : 1359-68. [PubMed 18846501]

-  MalaCards Disease Associations
  MalaCards Gene Search: KIF6
Diseases sorted by gene-association score: smallpox (10)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.40 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 12.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.7095-0.365 Picture PostScript Text
3' UTR -530.501432-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom

Pfam Domains:
PF00225 - Kinesin motor domain
PF16796 - Microtubule binding

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on F6VGH2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003777 microtubule motor activity

Biological Process:
GO:0007018 microtubule-based movement


-  Descriptions from all associated GenBank mRNAs
  KJ904031 - Synthetic construct Homo sapiens clone ccsbBroadEn_13425 KIF6 gene, encodes complete protein.
KR709508 - Synthetic construct Homo sapiens clone CCSBHm_00002861 KIF6 (KIF6) mRNA, encodes complete protein.
AL832634 - Homo sapiens mRNA; cDNA DKFZp451I2418 (from clone DKFZp451I2418).
AK123217 - Homo sapiens cDNA FLJ41223 fis, clone BRAMY2029602.
BX649045 - Homo sapiens mRNA; cDNA DKFZp779L1313 (from clone DKFZp779L1313).
BC022074 - Homo sapiens kinesin family member 6, mRNA (cDNA clone IMAGE:4798479), complete cds.
AK131471 - Homo sapiens cDNA FLJ16639 fis, clone TESTI4026207, weakly similar to Kinesin-like protein KLP1.
BC143444 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:176969 IMAGE:9051952), complete cds.
BC143445 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:176970 IMAGE:9051953), complete cds.
BC117307 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:150916 IMAGE:40125858), complete cds.
KJ904032 - Synthetic construct Homo sapiens clone ccsbBroadEn_13426 KIF6 gene, encodes complete protein.
BC098418 - Homo sapiens kinesin family member 6, mRNA (cDNA clone IMAGE:5420694), complete cds.
JD484485 - Sequence 465509 from Patent EP1572962.
JD209331 - Sequence 190355 from Patent EP1572962.
JD343760 - Sequence 324784 from Patent EP1572962.
JD234415 - Sequence 215439 from Patent EP1572962.
JD351346 - Sequence 332370 from Patent EP1572962.
JD342056 - Sequence 323080 from Patent EP1572962.
JD209168 - Sequence 190192 from Patent EP1572962.
JD215459 - Sequence 196483 from Patent EP1572962.
JD119601 - Sequence 100625 from Patent EP1572962.
JD102837 - Sequence 83861 from Patent EP1572962.
JD106350 - Sequence 87374 from Patent EP1572962.
JD386372 - Sequence 367396 from Patent EP1572962.
JD251435 - Sequence 232459 from Patent EP1572962.
JD372423 - Sequence 353447 from Patent EP1572962.
JD360221 - Sequence 341245 from Patent EP1572962.
BC043552 - Homo sapiens, clone IMAGE:5174044, mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: BC117307, F6VGH2, F6VGH2_HUMAN, NM_145027, NP_659464
UCSC ID: uc010jxb.1
RefSeq Accession: NM_145027
Protein: F6VGH2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC117307.1
exon count: 22CDS single in 3' UTR: no RNA size: 2361
ORF size: 2277CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 4754.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.