Description: Homo sapiens solute carrier family 22 (organic anion transporter), member 7 (SLC22A7), transcript variant 1, mRNA. RefSeq Summary (NM_153320): The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr6:43,265,998-43,270,633 Size: 4,636 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr6:43,266,097-43,270,505 Size: 4,409 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on Q9Y694-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF097518 - Homo sapiens liver-specific transporter (NLT) mRNA, complete cds. JD493187 - Sequence 474211 from Patent EP1572962. AK290806 - Homo sapiens cDNA FLJ78379 complete cds, highly similar to Homo sapiens organic anion transporter 2 mRNA. AK309570 - Homo sapiens cDNA, FLJ99611. JD206590 - Sequence 187614 from Patent EP1572962. AB571482 - Homo sapiens hOAT11 mRNA for organic anion transporter 11, complete cds. AK314822 - Homo sapiens cDNA, FLJ95700, highly similar to Homo sapiens solute carrier family 22 (organic anion transporter), member 7 (SLC22A7), transcript variant 2, mRNA. BC033805 - Homo sapiens solute carrier family 22 (organic anion transporter), member 7, mRNA (cDNA clone MGC:45202 IMAGE:5187472), complete cds. AK290796 - Homo sapiens cDNA FLJ76147 complete cds, highly similar to Homo sapiens solute carrier family 22 (organic anion transporter), member 7 (SLC22A7), transcript variant 1, mRNA. JD223265 - Sequence 204289 from Patent EP1572962. BC017963 - Homo sapiens solute carrier family 22 (organic anion transporter), member 7, mRNA (cDNA clone IMAGE:4610103), complete cds. KJ893146 - Synthetic construct Homo sapiens clone ccsbBroadEn_02540 SLC22A7 gene, encodes complete protein. DQ896844 - Synthetic construct Homo sapiens clone IMAGE:100011304; FLH182951.01L; RZPDo839E01139D solute carrier family 22 (organic anion transporter), member 7 (SLC22A7) gene, encodes complete protein. DQ893614 - Synthetic construct clone IMAGE:100006244; FLH182955.01X; RZPDo839E01140D solute carrier family 22 (organic anion transporter), member 7 (SLC22A7) gene, encodes complete protein. AF210455 - Homo sapiens organic anion transporter 2 mRNA, complete cds. AY050498 - Homo sapiens organic anion transporter 2 (SLC22A7) mRNA, complete cds. JD454140 - Sequence 435164 from Patent EP1572962. JD279414 - Sequence 260438 from Patent EP1572962. JD393556 - Sequence 374580 from Patent EP1572962. JD396460 - Sequence 377484 from Patent EP1572962. JD091055 - Sequence 72079 from Patent EP1572962. JD159926 - Sequence 140950 from Patent EP1572962. JD267904 - Sequence 248928 from Patent EP1572962. JD206327 - Sequence 187351 from Patent EP1572962. JD217765 - Sequence 198789 from Patent EP1572962. JD261176 - Sequence 242200 from Patent EP1572962. JD160972 - Sequence 141996 from Patent EP1572962. JD403557 - Sequence 384581 from Patent EP1572962. JD222123 - Sequence 203147 from Patent EP1572962. JD455791 - Sequence 436815 from Patent EP1572962. JD445283 - Sequence 426307 from Patent EP1572962. JD043257 - Sequence 24281 from Patent EP1572962. JD131180 - Sequence 112204 from Patent EP1572962. JD318998 - Sequence 300022 from Patent EP1572962. JD057043 - Sequence 38067 from Patent EP1572962. JD466395 - Sequence 447419 from Patent EP1572962. JD081061 - Sequence 62085 from Patent EP1572962. JD298494 - Sequence 279518 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y694 (Reactome details) participates in the following event(s):
R-HSA-561059 OAT2 and OAT4 mediate transport of sulphate conjugates R-HSA-561041 OAT1-3 transport organic anions with antiport of dicarboxylic acids R-HSA-561048 Organic anion transport R-HSA-549132 Organic cation/anion/zwitterion transport R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules