Human Gene SLC22A7 (uc010jyl.1)
  Description: Homo sapiens solute carrier family 22 (organic anion transporter), member 7 (SLC22A7), transcript variant 1, mRNA.
RefSeq Summary (NM_153320): The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr6:43,265,998-43,270,633 Size: 4,636 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr6:43,266,097-43,270,505 Size: 4,409 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:43,265,998-43,270,633)mRNA (may differ from genome)Protein (463 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMalacardsMGI
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLC22A7
CDC HuGE Published Literature: SLC22A7

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC22A7
Diseases sorted by gene-association score: bilirubin metabolic disorder (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 77.79 RPKM in Liver
Total median expression: 86.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.1099-0.314 Picture PostScript Text
3' UTR -23.45128-0.183 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00083 - Sugar (and other) transporter
PF07690 - Major Facilitator Superfamily

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q9Y694-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AF097518 - Homo sapiens liver-specific transporter (NLT) mRNA, complete cds.
JD493187 - Sequence 474211 from Patent EP1572962.
AK290806 - Homo sapiens cDNA FLJ78379 complete cds, highly similar to Homo sapiens organic anion transporter 2 mRNA.
AK309570 - Homo sapiens cDNA, FLJ99611.
JD206590 - Sequence 187614 from Patent EP1572962.
AB571482 - Homo sapiens hOAT11 mRNA for organic anion transporter 11, complete cds.
AK314822 - Homo sapiens cDNA, FLJ95700, highly similar to Homo sapiens solute carrier family 22 (organic anion transporter), member 7 (SLC22A7), transcript variant 2, mRNA.
BC033805 - Homo sapiens solute carrier family 22 (organic anion transporter), member 7, mRNA (cDNA clone MGC:45202 IMAGE:5187472), complete cds.
AK290796 - Homo sapiens cDNA FLJ76147 complete cds, highly similar to Homo sapiens solute carrier family 22 (organic anion transporter), member 7 (SLC22A7), transcript variant 1, mRNA.
JD223265 - Sequence 204289 from Patent EP1572962.
BC017963 - Homo sapiens solute carrier family 22 (organic anion transporter), member 7, mRNA (cDNA clone IMAGE:4610103), complete cds.
KJ893146 - Synthetic construct Homo sapiens clone ccsbBroadEn_02540 SLC22A7 gene, encodes complete protein.
DQ896844 - Synthetic construct Homo sapiens clone IMAGE:100011304; FLH182951.01L; RZPDo839E01139D solute carrier family 22 (organic anion transporter), member 7 (SLC22A7) gene, encodes complete protein.
DQ893614 - Synthetic construct clone IMAGE:100006244; FLH182955.01X; RZPDo839E01140D solute carrier family 22 (organic anion transporter), member 7 (SLC22A7) gene, encodes complete protein.
AF210455 - Homo sapiens organic anion transporter 2 mRNA, complete cds.
AY050498 - Homo sapiens organic anion transporter 2 (SLC22A7) mRNA, complete cds.
JD454140 - Sequence 435164 from Patent EP1572962.
JD279414 - Sequence 260438 from Patent EP1572962.
JD393556 - Sequence 374580 from Patent EP1572962.
JD396460 - Sequence 377484 from Patent EP1572962.
JD091055 - Sequence 72079 from Patent EP1572962.
JD159926 - Sequence 140950 from Patent EP1572962.
JD267904 - Sequence 248928 from Patent EP1572962.
JD206327 - Sequence 187351 from Patent EP1572962.
JD217765 - Sequence 198789 from Patent EP1572962.
JD261176 - Sequence 242200 from Patent EP1572962.
JD160972 - Sequence 141996 from Patent EP1572962.
JD403557 - Sequence 384581 from Patent EP1572962.
JD222123 - Sequence 203147 from Patent EP1572962.
JD455791 - Sequence 436815 from Patent EP1572962.
JD445283 - Sequence 426307 from Patent EP1572962.
JD043257 - Sequence 24281 from Patent EP1572962.
JD131180 - Sequence 112204 from Patent EP1572962.
JD318998 - Sequence 300022 from Patent EP1572962.
JD057043 - Sequence 38067 from Patent EP1572962.
JD466395 - Sequence 447419 from Patent EP1572962.
JD081061 - Sequence 62085 from Patent EP1572962.
JD298494 - Sequence 279518 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y694 (Reactome details) participates in the following event(s):

R-HSA-561059 OAT2 and OAT4 mediate transport of sulphate conjugates
R-HSA-561041 OAT1-3 transport organic anions with antiport of dicarboxylic acids
R-HSA-561048 Organic anion transport
R-HSA-549132 Organic cation/anion/zwitterion transport
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: AK309570, NLT, NM_153320, NP_696961, OAT2, Q9Y694-3
UCSC ID: uc010jyl.1
RefSeq Accession: NM_153320
Protein: Q9Y694-3, splice isoform of Q9Y694

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK309570.1
exon count: 8CDS single in 3' UTR: no RNA size: 1581
ORF size: 1392CDS single in intron: no Alignment % ID: 99.87
txCdsPredict score: 2891.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 132# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.