Human Gene ANKIB1 (uc010lew.1)
  Description: Homo sapiens ankyrin repeat and IBR domain containing 1 (ANKIB1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:92,000,791-92,030,698 Size: 29,908 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr7:92,020,569-92,028,263 Size: 7,695 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:92,000,791-92,030,698)mRNA (may differ from genome)Protein (358 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIPubMedTreefam
UniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ANKIB1
CDC HuGE Published Literature: ANKIB1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.49 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 404.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -162.04655-0.247 Picture PostScript Text
3' UTR -592.302435-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003903 - Ubiquitin-int_motif

Pfam Domains:
PF02809 - Ubiquitin interaction motif

ModBase Predicted Comparative 3D Structure on Q4VBX8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0016567 protein ubiquitination


-  Descriptions from all associated GenBank mRNAs
  AB037807 - Homo sapiens KIAA1386 mRNA for KIAA1386 protein.
BC063861 - Homo sapiens ankyrin repeat and IBR domain containing 1, mRNA (cDNA clone IMAGE:6469676), partial cds.
AB385463 - Synthetic construct DNA, clone: pF1KA1386, Homo sapiens ANKIB1 gene for ankyrin repeat and IBR domain-containing protein 1, complete cds, without stop codon, in Flexi system.
AK025475 - Homo sapiens cDNA: FLJ21822 fis, clone HEP01316.
BC073893 - Homo sapiens ankyrin repeat and IBR domain containing 1, mRNA (cDNA clone IMAGE:3921597), partial cds.
BC031483 - Homo sapiens ankyrin repeat and IBR domain containing 1, mRNA (cDNA clone IMAGE:3445463), partial cds.
BC041643 - Homo sapiens ankyrin repeat and IBR domain containing 1, mRNA (cDNA clone IMAGE:5018638), containing frame-shift errors.
AK001179 - Homo sapiens cDNA FLJ10317 fis, clone NT2RM2000452.
AL137349 - Homo sapiens mRNA; cDNA DKFZp434A0225 (from clone DKFZp434A0225).
BC094865 - Homo sapiens ankyrin repeat and IBR domain containing 1, mRNA (cDNA clone IMAGE:5088866), partial cds.
JD093516 - Sequence 74540 from Patent EP1572962.
JD243734 - Sequence 224758 from Patent EP1572962.
JD495643 - Sequence 476667 from Patent EP1572962.
JD146367 - Sequence 127391 from Patent EP1572962.
JD323368 - Sequence 304392 from Patent EP1572962.
JD530738 - Sequence 511762 from Patent EP1572962.
JD302009 - Sequence 283033 from Patent EP1572962.
JD519225 - Sequence 500249 from Patent EP1572962.
JD556569 - Sequence 537593 from Patent EP1572962.
JD181738 - Sequence 162762 from Patent EP1572962.
AK057685 - Homo sapiens cDNA FLJ33123 fis, clone TRACH2001432.
JD110004 - Sequence 91028 from Patent EP1572962.
JD359218 - Sequence 340242 from Patent EP1572962.
JD299328 - Sequence 280352 from Patent EP1572962.
JD330737 - Sequence 311761 from Patent EP1572962.
JD312296 - Sequence 293320 from Patent EP1572962.
JD521127 - Sequence 502151 from Patent EP1572962.
JD130943 - Sequence 111967 from Patent EP1572962.
JD422288 - Sequence 403312 from Patent EP1572962.
JD357959 - Sequence 338983 from Patent EP1572962.
JD167369 - Sequence 148393 from Patent EP1572962.
JD501802 - Sequence 482826 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC041643, Q4VBX8, Q4VBX8_HUMAN
UCSC ID: uc010lew.1
RefSeq Accession: NM_019004
Protein: Q4VBX8

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC041643.1
exon count: 9CDS single in 3' UTR: no RNA size: 2040
ORF size: 1077CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 1771.00frame shift in genome: no % Coverage: 99.22
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.