Human Gene MOGAT3 (uc010lhr.3)
  Description: Homo sapiens monoacylglycerol O-acyltransferase 3 (MOGAT3), mRNA.
RefSeq Summary (NM_178176): Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr7:100,839,013-100,844,302 Size: 5,290 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr7:100,839,204-100,844,135 Size: 4,932 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:100,839,013-100,844,302)mRNA (may differ from genome)Protein (281 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkHGNC
LynxMGIPubMedReactomeTreefamUniProtKB
Wikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.41 RPKM in Small Intestine - Terminal Ileum
Total median expression: 40.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.50167-0.314 Picture PostScript Text
3' UTR -68.70191-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF03982 - Diacylglycerol acyltransferase

ModBase Predicted Comparative 3D Structure on Q86VF5-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  JD277586 - Sequence 258610 from Patent EP1572962.
AY229854 - Homo sapiens acyl coenzyme A:monoacylglycerol acyltransferase 3 (MGAT3) mRNA, complete cds.
JD277585 - Sequence 258609 from Patent EP1572962.
JD118527 - Sequence 99551 from Patent EP1572962.
JD118528 - Sequence 99552 from Patent EP1572962.
JD332088 - Sequence 313112 from Patent EP1572962.
JD443015 - Sequence 424039 from Patent EP1572962.
JD558825 - Sequence 539849 from Patent EP1572962.
JD564634 - Sequence 545658 from Patent EP1572962.
JD257914 - Sequence 238938 from Patent EP1572962.
JD178699 - Sequence 159723 from Patent EP1572962.
JD373786 - Sequence 354810 from Patent EP1572962.
JD362370 - Sequence 343394 from Patent EP1572962.
JD387693 - Sequence 368717 from Patent EP1572962.
JD216510 - Sequence 197534 from Patent EP1572962.
AY358200 - Homo sapiens clone DNA213516 GVAT9383 (UNQ9383) mRNA, complete cds.
JD474124 - Sequence 455148 from Patent EP1572962.
JD044705 - Sequence 25729 from Patent EP1572962.
JD361879 - Sequence 342903 from Patent EP1572962.
JD456490 - Sequence 437514 from Patent EP1572962.
BC100953 - Homo sapiens monoacylglycerol O-acyltransferase 3, mRNA (cDNA clone MGC:119202 IMAGE:40004561), complete cds.
BC100954 - Homo sapiens monoacylglycerol O-acyltransferase 3, mRNA (cDNA clone MGC:119203 IMAGE:40004562), complete cds.
BC100955 - Homo sapiens monoacylglycerol O-acyltransferase 3, mRNA (cDNA clone MGC:119204 IMAGE:40004564), complete cds.
JD288389 - Sequence 269413 from Patent EP1572962.
KJ900658 - Synthetic construct Homo sapiens clone ccsbBroadEn_10052 MOGAT3 gene, encodes complete protein.
KJ904216 - Synthetic construct Homo sapiens clone ccsbBroadEn_13610 MOGAT3 gene, encodes complete protein.
JD077143 - Sequence 58167 from Patent EP1572962.
JD409347 - Sequence 390371 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86VF5 (Reactome details) participates in the following event(s):

R-HSA-6800334 MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG
R-HSA-75109 Triglyceride biosynthesis
R-HSA-8979227 Triglyceride metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: BC100955, DC7, DGAT2L7, Q86VF5-2, UNQ9383/PRO34208
UCSC ID: uc010lhr.3
RefSeq Accession: NM_178176
Protein: Q86VF5-2, splice isoform of Q86VF5

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC100955.1
exon count: 6CDS single in 3' UTR: no RNA size: 933
ORF size: 846CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1757.00frame shift in genome: no % Coverage: 99.68
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.