Human Gene TMEM213 (uc010lna.3)
  Description: Homo sapiens transmembrane protein 213 (TMEM213), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:138,482,739-138,490,769 Size: 8,031 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr7:138,482,850-138,487,814 Size: 4,965 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:138,482,739-138,490,769)mRNA (may differ from genome)Protein (107 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM213_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 213; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SEQUENCE CAUTION: Sequence=AAI31698.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.74 RPKM in Kidney - Cortex
Total median expression: 44.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.10111-0.361 Picture PostScript Text
3' UTR -980.462955-0.332 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15192 - TMEM213 family

ModBase Predicted Comparative 3D Structure on A2RRL7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ903903 - Synthetic construct Homo sapiens clone ccsbBroadEn_13297 TMEM213 gene, encodes complete protein.
BC131697 - Homo sapiens transmembrane protein 213, mRNA (cDNA clone MGC:150427 IMAGE:40120595), complete cds.
AK055841 - Homo sapiens cDNA FLJ31279 fis, clone KIDNE2006652.
BC058028 - Homo sapiens hypothetical protein LOC155006, mRNA (cDNA clone IMAGE:4594371), partial cds.
JD501936 - Sequence 482960 from Patent EP1572962.
JD175070 - Sequence 156094 from Patent EP1572962.
AK055760 - Homo sapiens cDNA FLJ31198 fis, clone KIDNE2000543.
JD562911 - Sequence 543935 from Patent EP1572962.
JD042598 - Sequence 23622 from Patent EP1572962.
JD121058 - Sequence 102082 from Patent EP1572962.
JD122127 - Sequence 103151 from Patent EP1572962.
JD040660 - Sequence 21684 from Patent EP1572962.
JD374500 - Sequence 355524 from Patent EP1572962.
JD353592 - Sequence 334616 from Patent EP1572962.
JD167602 - Sequence 148626 from Patent EP1572962.
JD344151 - Sequence 325175 from Patent EP1572962.
JD483168 - Sequence 464192 from Patent EP1572962.
JD430408 - Sequence 411432 from Patent EP1572962.
JD529595 - Sequence 510619 from Patent EP1572962.
JD170037 - Sequence 151061 from Patent EP1572962.
JD170038 - Sequence 151062 from Patent EP1572962.
JD366564 - Sequence 347588 from Patent EP1572962.
JD366565 - Sequence 347589 from Patent EP1572962.
JD366566 - Sequence 347590 from Patent EP1572962.
JD517742 - Sequence 498766 from Patent EP1572962.
JD517745 - Sequence 498769 from Patent EP1572962.
JD105965 - Sequence 86989 from Patent EP1572962.
JD105966 - Sequence 86990 from Patent EP1572962.
JD090340 - Sequence 71364 from Patent EP1572962.
JD491223 - Sequence 472247 from Patent EP1572962.
JD370178 - Sequence 351202 from Patent EP1572962.
JD167272 - Sequence 148296 from Patent EP1572962.
JD265969 - Sequence 246993 from Patent EP1572962.
JD166446 - Sequence 147470 from Patent EP1572962.
JD563479 - Sequence 544503 from Patent EP1572962.
JD508277 - Sequence 489301 from Patent EP1572962.
JD442902 - Sequence 423926 from Patent EP1572962.
JD558728 - Sequence 539752 from Patent EP1572962.
JD558727 - Sequence 539751 from Patent EP1572962.
JD442901 - Sequence 423925 from Patent EP1572962.
JD118069 - Sequence 99093 from Patent EP1572962.
JD556467 - Sequence 537491 from Patent EP1572962.
JD441463 - Sequence 422487 from Patent EP1572962.
JD117225 - Sequence 98249 from Patent EP1572962.
JD277690 - Sequence 258714 from Patent EP1572962.
JD096515 - Sequence 77539 from Patent EP1572962.
JD495728 - Sequence 476752 from Patent EP1572962.
JD063117 - Sequence 44141 from Patent EP1572962.
JD557888 - Sequence 538912 from Patent EP1572962.
JD324907 - Sequence 305931 from Patent EP1572962.
JD149550 - Sequence 130574 from Patent EP1572962.
JD371641 - Sequence 352665 from Patent EP1572962.
JD351291 - Sequence 332315 from Patent EP1572962.
JD252104 - Sequence 233128 from Patent EP1572962.
JD467011 - Sequence 448035 from Patent EP1572962.
JD428041 - Sequence 409065 from Patent EP1572962.
JD124519 - Sequence 105543 from Patent EP1572962.
JD520215 - Sequence 501239 from Patent EP1572962.
JD426999 - Sequence 408023 from Patent EP1572962.
JD427303 - Sequence 408327 from Patent EP1572962.
JD427304 - Sequence 408328 from Patent EP1572962.
JD528653 - Sequence 509677 from Patent EP1572962.
JD425215 - Sequence 406239 from Patent EP1572962.
JD117653 - Sequence 98677 from Patent EP1572962.
JD426992 - Sequence 408016 from Patent EP1572962.
JD427220 - Sequence 408244 from Patent EP1572962.
JD325710 - Sequence 306734 from Patent EP1572962.
JD557216 - Sequence 538240 from Patent EP1572962.
JD066585 - Sequence 47609 from Patent EP1572962.
JD247679 - Sequence 228703 from Patent EP1572962.
JD374589 - Sequence 355613 from Patent EP1572962.
JD489404 - Sequence 470428 from Patent EP1572962.
JD530280 - Sequence 511304 from Patent EP1572962.
JD059117 - Sequence 40141 from Patent EP1572962.
JD064721 - Sequence 45745 from Patent EP1572962.
JD293859 - Sequence 274883 from Patent EP1572962.
JD066508 - Sequence 47532 from Patent EP1572962.
JD421162 - Sequence 402186 from Patent EP1572962.
JD532453 - Sequence 513477 from Patent EP1572962.
JD134074 - Sequence 115098 from Patent EP1572962.
JD420977 - Sequence 402001 from Patent EP1572962.
JD481613 - Sequence 462637 from Patent EP1572962.
FV525720 - Nucleic acid controling mast cell degranulation.
HI965489 - Sequence 774 from Patent WO2010139812.
HI966450 - Sequence 770 from Patent WO2010139811.
HI967316 - Sequence 770 from Patent WO2010139810.
HV594843 - JP 2010539959-A/224: Micromirs.
HW122410 - JP 2013504331-A/69: MICRO-RNA, AUTOANTIBODY AND PROTEIN MARKERS FOR DIAGNOSIS OF NEURONAL INJURY.
HW906863 - WO 2015037656-A/78: Autophagy-regulating microRNA.
HZ074673 - JP 2013535982-A/764: Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer.
HZ083107 - JP 2015513906-A/464: Stem Cell Microparticles.
HZ157400 - JP 2015130862-A/224: Micromirs.
HZ436888 - JP 2015529450-A/464: Stem Cell Microparticles.
HZ479742 - JP 2015535430-A/248: TERMINALLY MODIFIED RNA.
HZ789673 - JP 2016504050-A/1418: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JA401527 - Sequence 774 from Patent WO2011080318.
JA402505 - Sequence 774 from Patent WO2011080315.
JA403512 - Sequence 774 from Patent WO2011080316.
JA406143 - Sequence 774 from Patent EP2336353.
JA429669 - Sequence 774 from Patent WO2011095623.
JA660671 - Sequence 125 from Patent WO2011131354.
JA682587 - Sequence 55 from Patent WO2011149354.
JB022357 - Sequence 199 from Patent WO2013026685.
JB023168 - Sequence 422 from Patent WO2013026684.
JB074968 - Sequence 228 from Patent WO2012168448.
JB249345 - Sequence 113 from Patent EP2478360.
JB620858 - Sequence 838 from Patent WO2013063544.
JB770380 - Sequence 7 from Patent EP2604690.
JC008808 - Sequence 7 from Patent WO2013088338.
JC172092 - Sequence 464 from Patent WO2013150303.
JC512405 - Sequence 2658 from Patent WO2014113089.
JC572903 - Sequence 464 from Patent WO2014125276.
JC582591 - Sequence 464 from Patent WO2014125277.
JC963972 - Sequence 7 from Patent EP2816114.
JE954287 - Sequence 464 from Patent WO2015052526.
JE956040 - Sequence 464 from Patent WO2015052527.
JE978680 - Sequence 125 from Patent EP2865765.
LF137792 - JP 2016507550-A/464: Method of Producing Microparticles.
LF160297 - JP 2016513950-A/363: Oligomers with improved off-target profile.
LF162757 - JP 2016513095-A/464: Stem Cell Microparticles and miRNA.
LF953509 - JP 2016534103-A/464: Stem Cell Microparticles and miRNA.
LG005854 - KR 1020150004822-A/464: STEM CELL MICROPARTICLES.
LG053550 - KR 1020150059168-A/464: STEM CELL MICROPARTICLES.
LG240789 - KR 1020160035087-A/464: STEM CELL MICROPARTICLES AND MIRNA.
LP643893 - Sequence 51 from Patent WO2015091892.
LP727076 - Sequence 770 from Patent EP2883966.
LP819346 - Sequence 770 from Patent EP3296406.
LP939288 - Sequence 770 from Patent EP3184651.
LP951763 - Sequence 269 from Patent WO2017157650.
LQ069993 - Sequence 317 from Patent EP2964234.
LQ441221 - Sequence 228 from Patent EP3029157.
LQ565026 - Sequence 51 from Patent WO2016139092.
LV470874 - JP 2016534036-A/464: Stem Cell Microparticles and miRNA.
LX280782 - JP 2016105097-A/69: MICRO-RNA, AUTOANTIBODY AND PROTEIN MARKERS FOR DIAGNOSIS OF NEURONAL INJURY.
LY404908 - KR 1020160117535-A/213: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
LZ234400 - JP 2017181518-A/69: MICRO-RNA, AUTOANTIBODY AND PROTEIN MARKERS FOR DIAGNOSIS OF NEURONAL INJURY.
MA260147 - JP 2017505623-A/213: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
MS673619 - Sequence 422 from Patent EP3135774.
MS834628 - Sequence 774 from Patent EP3112479.
MS901726 - Sequence 199 from Patent EP3156505.
MA643494 - JP 2017113010-A/1418: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA731378 - JP 2017140048-A/248: TERMINALLY MODIFIED RNA.
MA405522 - WO 2018155427-A/296: A probe with reduced false positive binding, a method to desing the probe, and the use thereof.
MP015114 - Sequence 317 from Patent WO2019016252.
MA800547 - JP 2018183181-A/1418: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MP129564 - Sequence 464 from Patent EP3470073.
MP162487 - Sequence 464 from Patent WO2019069093.
MB017919 - JP 2018506997-A/51: SIGNATURE OF HEALTH.
MP395081 - Sequence 179 from Patent EP3565903.
MP325458 - Sequence 5 from Patent EP3536789.

-  Other Names for This Gene
  Alternate Gene Symbols: A2RRL7, A4D1R3, C9JH49, C9JX41, C9K0P0, NM_001085429, NP_001078898, TM213_HUMAN
UCSC ID: uc010lna.3
RefSeq Accession: NM_001085429
Protein: A2RRL7 (aka TM213_HUMAN)
CCDS: CCDS47722.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001085429.1
exon count: 3CDS single in 3' UTR: no RNA size: 3398
ORF size: 324CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 848.00frame shift in genome: no % Coverage: 99.76
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.