Human Gene DOCK5 (uc010luf.1)
  Description: Homo sapiens dedicator of cytokinesis 5 (DOCK5), mRNA.
RefSeq Summary (NM_024940): This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Transcript (Including UTRs)
   Position: hg19 chr8:25,042,287-25,230,234 Size: 187,948 Total Exon Count: 35 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:25,042,287-25,230,234)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerGeneNetworkH-INVHGNC
LynxPubMedTreefamWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DOCK5
CDC HuGE Published Literature: DOCK5
Positive Disease Associations: Myocardial Infarction
Related Studies:
  1. Myocardial Infarction
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.94 RPKM in Nerve - Tibial
Total median expression: 197.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK123607 - Homo sapiens cDNA FLJ41613 fis, clone CTONG3002412, moderately similar to Human DOCK180 protein mRNA.
BC137175 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone MGC:168795 IMAGE:9021172), complete cds.
BC137176 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone MGC:168796 IMAGE:9021173), complete cds.
CR749353 - Homo sapiens mRNA; cDNA DKFZp781J211 (from clone DKFZp781J211).
AK130123 - Homo sapiens cDNA FLJ26613 fis, clone MPB05565, highly similar to Serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform.
BC015352 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone IMAGE:4429918), with apparent retained intron.
BC011877 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone IMAGE:3347029), complete cds.
JD129072 - Sequence 110096 from Patent EP1572962.
KJ903262 - Synthetic construct Homo sapiens clone ccsbBroadEn_12656 DOCK5 gene, encodes complete protein.
AL832744 - Homo sapiens mRNA; cDNA DKFZp686P1513 (from clone DKFZp686P1513).
CR933718 - Homo sapiens mRNA; cDNA DKFZp779M164 (from clone DKFZp779M164).
BX648352 - Homo sapiens mRNA; cDNA DKFZp686D14185 (from clone DKFZp686D14185).
AK024569 - Homo sapiens cDNA: FLJ20916 fis, clone ADSE00738, highly similar to AF161512 Homo sapiens HSPC163 mRNA.
AK126249 - Homo sapiens cDNA FLJ44261 fis, clone TLIVE2001327, moderately similar to Human DOCK180 protein mRNA.
BC041761 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone IMAGE:3912471), partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AK123607
UCSC ID: uc010luf.1
RefSeq Accession: NM_024940

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: AK123607.1
exon count: 35CDS single in 3' UTR: no RNA size: 3812
ORF size: 0CDS single in intron: no Alignment % ID: 99.84
txCdsPredict score: 3004.00frame shift in genome: no % Coverage: 99.76
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.