Description: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB), transcript variant 6, non-coding RNA. RefSeq Summary (NR_033819): The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr8:42,128,820-42,190,171 Size: 61,352 Total Exon Count: 21 Strand: +
Arthritis, Rheumatoid|Rheumatoid Arthritis|Anti-TNF Response Potter C et al. 2010, Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways., Annals of the rheumatic diseases 69(7) : 1315-20 2010.
[PubMed 20448286]
Several SNPs mapping to the TLR and NFkappaB signalling systems demonstrated association with anti-TNF response as a whole and, in particular, with response to etanercept. Validation of these findings in an independent cohort is now warranted.
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK303528 - Homo sapiens cDNA FLJ58217 complete cds, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10). BC006231 - Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, mRNA (cDNA clone IMAGE:3945886), complete cds. AK303294 - Homo sapiens cDNA FLJ58658 complete cds, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10). AK316418 - Homo sapiens cDNA, FLJ79317 complete cds, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10). AK302723 - Homo sapiens cDNA FLJ57238 complete cds, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10). AK309052 - Homo sapiens cDNA, FLJ99093. AK091297 - Homo sapiens cDNA FLJ33978 fis, clone DFNES2004354, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10). BC090865 - Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, mRNA (cDNA clone IMAGE:6184761), with apparent retained intron. AF080158 - Homo sapiens IkB kinase-b (IKK-beta) mRNA, complete cds. AK298241 - Homo sapiens cDNA FLJ58600 complete cds, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10). AB209090 - Homo sapiens mRNA for inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta variant protein. BC108694 - Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, mRNA (cDNA clone MGC:131801 IMAGE:5784717), complete cds. JD128726 - Sequence 109750 from Patent EP1572962. AK290952 - Homo sapiens cDNA FLJ77419 complete cds. BC144080 - Homo sapiens cDNA clone IMAGE:9052600. BX648165 - Homo sapiens mRNA; cDNA DKFZp686J1040 (from clone DKFZp686J1040). HM245392 - Homo sapiens TNPO1-IKBKB breakpoint junction mRNA sequence. KJ891447 - Synthetic construct Homo sapiens clone ccsbBroadEn_00841 IKBKB gene, encodes complete protein. AB527730 - Synthetic construct DNA, clone: pF1KB6249, Homo sapiens IKBKB gene for inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, without stop codon, in Flexi system. AF029684 - Homo sapiens IkB kinase-beta (IKK-beta) mRNA, partial cds. AF031416 - Homo sapiens IkB kinase beta subunit mRNA, complete cds. AK023193 - Homo sapiens cDNA FLJ13131 fis, clone NT2RP3002988, highly similar to Homo sapiens IkB kinase-b (IKK-beta) mRNA. AK097828 - Homo sapiens cDNA FLJ40509 fis, clone TESTI2045964, highly similar to Homo sapiens IkB kinase-beta (IKK-beta) mRNA. BC127663 - Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, mRNA (cDNA clone IMAGE:40128020), partial cds. BC141978 - Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, mRNA (cDNA clone IMAGE:40128022), partial cds. BC110917 - Homo sapiens cDNA clone IMAGE:5756066, **** WARNING: chimeric clone ****. AK095687 - Homo sapiens cDNA FLJ38368 fis, clone FEBRA2001705. AK093537 - Homo sapiens cDNA FLJ36218 fis, clone THYMU2000775. AX748189 - Sequence 1714 from Patent EP1308459. AK091090 - Homo sapiens cDNA FLJ33771 fis, clone BRHIP2000506. AX746775 - Sequence 300 from Patent EP1308459. JD422438 - Sequence 403462 from Patent EP1572962. JD117392 - Sequence 98416 from Patent EP1572962. JD210232 - Sequence 191256 from Patent EP1572962. JD251551 - Sequence 232575 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04010 - MAPK signaling pathway hsa04062 - Chemokine signaling pathway hsa04210 - Apoptosis hsa04620 - Toll-like receptor signaling pathway hsa04621 - NOD-like receptor signaling pathway hsa04622 - RIG-I-like receptor signaling pathway hsa04623 - Cytosolic DNA-sensing pathway hsa04660 - T cell receptor signaling pathway hsa04662 - B cell receptor signaling pathway hsa04722 - Neurotrophin signaling pathway hsa04910 - Insulin signaling pathway hsa04920 - Adipocytokine signaling pathway hsa04930 - Type II diabetes mellitus hsa05120 - Epithelial cell signaling in Helicobacter pylori infection hsa05131 - Shigellosis hsa05142 - Chagas disease hsa05200 - Pathways in cancer hsa05212 - Pancreatic cancer hsa05215 - Prostate cancer hsa05220 - Chronic myeloid leukemia hsa05221 - Acute myeloid leukemia hsa05222 - Small cell lung cancer