Description: Homo sapiens multiple PDZ domain protein (MPDZ), transcript variant 2, mRNA. RefSeq Summary (NM_001261406): The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr9:13,105,703-13,140,038 Size: 34,336 Total Exon Count: 20 Strand: - Coding Region Position: hg19 chr9:13,106,964-13,140,021 Size: 33,058 Coding Exon Count: 20
alcohol consumption Boris Tabakoff , et al. BMC biology 2010 7():70, , BMC biology 2010 7():70.
[PubMed 19874574]
Alcohol Withdrawal Seizures|Alcoholism|Disease Models, Animal| Victor M Karpyak , et al. Alcoholism, clinical and experimental research 2009 33(4):712-21, Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry., Alcoholism, clinical and experimental research 2009 33(4):712-21.
[PubMed 19175764]
Sequencing of MPDZ gene in individuals with EA ancestry revealed no variations in the sites identical to those associated with AWS in mice.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B4DGX5
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
