Description: Homo sapiens transmembrane channel-like 1 (TMC1), mRNA. RefSeq Summary (NM_138691): This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297784.10/ ENSP00000297784.6 RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr9:75,242,837-75,451,267 Size: 208,431 Total Exon Count: 18 Strand: + Coding Region Position: hg19 chr9:75,355,111-75,451,007 Size: 95,897 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A4FUA6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.