Description: Homo sapiens growth factor independent 1B transcription repressor (GFI1B), transcript variant 2, mRNA. RefSeq Summary (NM_001135031): This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Transcript (Including UTRs) Position: hg19 chr9:135,853,894-135,867,084 Size: 13,191 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr9:135,862,066-135,866,437 Size: 4,372 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00096 - Zinc finger, C2H2 type PF12874 - Zinc-finger of C2H2 type PF13894 - C2H2-type zinc finger PF13912 - C2H2-type zinc finger
ModBase Predicted Comparative 3D Structure on Q5VTD9-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.