Description: Homo sapiens olfactomedin 1 (OLFM1), transcript variant 1, mRNA. RefSeq Summary (NM_014279): This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr9:137,979,817-138,013,030 Size: 33,214 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr9:137,979,836-138,012,024 Size: 32,189 Coding Exon Count: 6
ID:NOE1_HUMAN DESCRIPTION: RecName: Full=Noelin; AltName: Full=Neuronal olfactomedin-related ER localized protein; AltName: Full=Olfactomedin-1; Flags: Precursor; FUNCTION: Seems to play an important role in regulating the production of neural crest cells by the neural tube (By similarity). INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-1105073, EBI-529989; SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (Potential). SIMILARITY: Contains 1 olfactomedin-like domain.
Hemoglobin A, Glycosylated Andrew D Paterson et al. Diabetes 2010, A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose., Diabetes.
[PubMed 19875614]
A major locus for A1C and glucose in individuals with diabetes is near SORCS1. This may influence the design and analysis of genetic studies attempting to identify risk factors for long-term diabetic complications.
Hemoglobin A, Glycosylated Andrew D Paterson et al. Diabetes 2010, A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose., Diabetes.
[PubMed 19875614]
A major locus for A1C and glucose in individuals with diabetes is near SORCS1. This may influence the design and analysis of genetic studies attempting to identify risk factors for long-term diabetic complications.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99784
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003190 atrioventricular valve formation GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0023041 neuronal signal transduction GO:0030516 regulation of axon extension GO:0060317 cardiac epithelial to mesenchymal transition