Description: Homo sapiens WWC family member 3 (WWC3), mRNA. RefSeq Summary (NM_015691): This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]. Sequence Note: The coding sequence starts at the 5'-most in-frame start codon based on currently available transcript data for this gene. It is unclear if the represented protein is N-terminally complete by comparison to other WWC family members. Transcript (Including UTRs) Position: hg19 chrX:9,983,795-10,112,518 Size: 128,724 Total Exon Count: 24 Strand: + Coding Region Position: hg19 chrX:10,084,492-10,109,541 Size: 25,050 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULE0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0019900 kinase binding GO:0032947 protein complex scaffold
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0035331 negative regulation of hippo signaling GO:0046621 negative regulation of organ growth
US Server
