Description: Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA. RefSeq Summary (NM_000061): The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]. Transcript (Including UTRs) Position: hg19 chrX:100,604,435-100,641,212 Size: 36,778 Total Exon Count: 17 Strand: - Coding Region Position: hg19 chrX:100,604,873-100,630,272 Size: 25,400 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5JY90
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KF241986 - Homo sapiens truncated Bruton agammaglobulinemia tyrosine kinase (BTK) mRNA, complete cds. AK057105 - Homo sapiens cDNA FLJ32543 fis, clone SMINT2000538, highly similar to Tyrosine-protein kinase BTK (EC 2.7.10.2). X58957 - H.sapiens atk mRNA for agammaglobulinaemia tyrosine kinase. AM051281 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 7 (BTK kinase deficient isoform 7 gene), cell type TEL-AML1+ leukemia cells. BC109079 - Homo sapiens Bruton agammaglobulinemia tyrosine kinase, mRNA (cDNA clone MGC:126261 IMAGE:40034287), complete cds. BC109080 - Homo sapiens Bruton agammaglobulinemia tyrosine kinase, mRNA (cDNA clone MGC:126262 IMAGE:40034289), complete cds. JD101417 - Sequence 82441 from Patent EP1572962. AM051275 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 1 (BTK kinase deficient isoform 1 gene), cell type BCR-ABL1+ and MLL-AF4+ leukemia cells. AM051276 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 2 (BTK kinase deficient isoform 2 gene), cell type MLL-AF4+ leukemia cells. AM051277 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 3 (BTK kinase deficient isoform 3 gene), cell type MLL-AF4+ leukemia cells. AM051278 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 4 (BTK kinase deficient isoform 4 gene), cell type BCR-ABL1+ leukemia cells. AM051279 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 5 (BTK kinase deficient isoform 5 gene), cell type BCR-ABL1+ leukemia cells. AM051280 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 6 (BTK kinase deficient isoform 6 gene), cell type BCR-ABL1+ leukemia cells. AM051282 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 8 (BTK kinase deficient isoform 8 gene), cell type TEL-AML1+ leukemia cells. AM051283 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 9 (BTK kinase deficient isoform 9 gene), cell type TEL-AML1+ leukemia cells. AM051285 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 11 (BTK kinase deficient isoform 11 gene), cell type E2A-PBX1+ leukemia cells. AM051286 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 12 (BTK kinase deficient isoform 12 gene), cell type E2A-PBX1+ leukemia cells. AM051284 - Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 10 (BTK kinase deficient isoform 10 gene), cell type TEL-AML1+ leukemia cells. AK309851 - Homo sapiens cDNA, FLJ99892. AF153364 - Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153756 - Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153757 - Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153758 - Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153759 - Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153760 - Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153761 - Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153762 - Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153764 - Homo sapiens Bruton's tyrosine kinase mRNA, partial cds. AK314382 - Homo sapiens cDNA, FLJ95155, highly similar to Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA. KJ890786 - Synthetic construct Homo sapiens clone ccsbBroadEn_00180 BTK gene, encodes complete protein. KR711531 - Synthetic construct Homo sapiens clone CCSBHm_00025588 BTK (BTK) mRNA, encodes complete protein. KR711532 - Synthetic construct Homo sapiens clone CCSBHm_00025631 BTK (BTK) mRNA, encodes complete protein. KR711533 - Synthetic construct Homo sapiens clone CCSBHm_00025709 BTK (BTK) mRNA, encodes complete protein. KR711534 - Synthetic construct Homo sapiens clone CCSBHm_00025787 BTK (BTK) mRNA, encodes complete protein. AJ888376 - Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 65 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia. AJ888379 - Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform (lacking exon 13 to 17) (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia. AJ888380 - Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform (lacking exon 15 to 18) (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia. AB590081 - Synthetic construct DNA, clone: pFN21AE0996, Homo sapiens BTK gene for Bruton agammaglobulinemia tyrosine kinase, without stop codon, in Flexi system. AJ888378 - Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 52 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia. AJ888381 - Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform (lacking exon 14) (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia. AJ888377 - Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 51 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia. AK225577 - Homo sapiens mRNA for Bruton agammaglobulinemia tyrosine kinase variant, clone: LNG09949. AF153763 - Homo sapiens Bruton's tyrosine kinase mRNA, partial cds. DL491428 - Novel nucleic acids. AF153755 - Homo sapiens Bruton's tyrosine kinase mRNA, partial cds. JD284811 - Sequence 265835 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04662 - B cell receptor signaling pathway hsa04664 - Fc epsilon RI signaling pathway hsa05340 - Primary immunodeficiency
BioCarta from NCI Cancer Genome Anatomy Project h_bcrPathway - BCR Signaling Pathway h_ptdinsPathway - Phosphoinositides and their downstream targets. h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells