Description: Homo sapiens pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1), mRNA. RefSeq Summary (NM_020524): The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr1:154,916,559-154,928,567 Size: 12,009 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr1:154,917,500-154,920,786 Size: 3,287 Coding Exon Count: 6
ID:PBIP1_HUMAN DESCRIPTION: RecName: Full=Pre-B-cell leukemia transcription factor-interacting protein 1; AltName: Full=Hematopoietic PBX-interacting protein; FUNCTION: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. SUBUNIT: Interacts with ESR1, PBX1, PBX2 and PBX3. INTERACTION: Q9Y3C0:CCDC53; NbExp=3; IntAct=EBI-740845, EBI-712969; P03372:ESR1; NbExp=9; IntAct=EBI-740845, EBI-78473; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus. TISSUE SPECIFICITY: Expressed in early hematopoietic precursors. DOMAIN: The C-terminal domain (AA 443-731) contains a nuclear export signal. DOMAIN: Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96AQ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
