Description: Homo sapiens olfactory receptor, family 10, subfamily J, member 3 (OR10J3), mRNA. RefSeq Summary (NM_001004467): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr1:159,283,460-159,284,449 Size: 990 Total Exon Count: 1 Strand: - Coding Region Position: hg19 chr1:159,283,460-159,284,449 Size: 990 Coding Exon Count: 1
plasma chemerin levels Bozaoglu ,et al. J Clin Endocrinol Metab 2010, Chemerin, a Novel Adipokine in the Regulation of Angiogenesis , The Journal of clinical endocrinology and metabolism 2010 .
[PubMed 20237162]
select biomarker traits Benjamin ,et al. 2007, Genome-wide association with select biomarker traits in the Framingham Heart Study, BMC medical genetics 2007 8 Suppl 1 : S11.
[PubMed 17903293]
The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability.
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 0.05 RPKM in Cells - Cultured fibroblasts
Total median expression: 0.05 RPKM
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q5JRS4
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007608 sensory perception of smell GO:0050896 response to stimulus GO:0050907 detection of chemical stimulus involved in sensory perception GO:0050911 detection of chemical stimulus involved in sensory perception of smell
AB529279 - Synthetic construct DNA, clone: pF1KE0859, Homo sapiens OR10J3 gene for olfactory receptor, family 10, subfamily J, member 3, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04740 - Olfactory transduction
Reactome (by CSHL, EBI, and GO)
Protein Q5JRS4 (Reactome details) participates in the following event(s):