Description: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, mRNA. RefSeq Summary (NM_001077474): This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]. Transcript (Including UTRs) Position: hg19 chr1:161,200,721-161,208,000 Size: 7,280 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr1:161,201,096-161,206,355 Size: 5,260 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B7Z8R7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
HQ447449 - Synthetic construct Homo sapiens clone IMAGE:100070777; CCSB013990_01 nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene, encodes complete protein. KJ898127 - Synthetic construct Homo sapiens clone ccsbBroadEn_07521 NR1I3 gene, encodes complete protein. KR711359 - Synthetic construct Homo sapiens clone CCSBHm_00023120 NR1I3 (NR1I3) mRNA, encodes complete protein. KR711360 - Synthetic construct Homo sapiens clone CCSBHm_00023121 NR1I3 (NR1I3) mRNA, encodes complete protein. Z30425 - H.sapiens mRNA for orphan nuclear hormone receptor. BC069626 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:97209 IMAGE:7262456), complete cds. BC069651 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:97144 IMAGE:7262385), complete cds. AY572806 - Homo sapiens constitutive androstane receptor SV1 (NR1I3) mRNA, partial cds, alternatively spliced. AY572807 - Homo sapiens constitutive androstane receptor SV2 (NR1I3) mRNA, complete cds, alternatively spliced. AY572808 - Homo sapiens constitutive androstane receptor SV3 (NR1I3) mRNA, complete cds, alternatively spliced. AY572809 - Homo sapiens constitutive androstane receptor SV4 (NR1I3) mRNA, complete cds, alternatively spliced. AY572810 - Homo sapiens constitutive androstane receptor SV5 (NR1I3) mRNA, complete cds, alternatively spliced. AY572811 - Homo sapiens constitutive androstane receptor SV6 (NR1I3) mRNA, complete cds, alternatively spliced. AY572812 - Homo sapiens constitutive androstane receptor SV7 (NR1I3) mRNA, partial cds, alternatively spliced. AY572813 - Homo sapiens constitutive androstane receptor SV8 (NR1I3) mRNA, partial cds, alternatively spliced. AY572814 - Homo sapiens constitutive androstane receptor SV9 (NR1I3) mRNA, complete cds, alternatively spliced. AY572815 - Homo sapiens constitutive androstane receptor SV10 (NR1I3) mRNA, complete cds, alternatively spliced. AY572816 - Homo sapiens constitutive androstane receptor SV11 (NR1I3) mRNA, partial cds, alternatively spliced. AY572817 - Homo sapiens constitutive androstane receptor SV12 (NR1I3) mRNA, partial cds, alternatively spliced. AY572818 - Homo sapiens constitutive androstane receptor SV13 (NR1I3) mRNA, partial cds, alternatively spliced. AY572819 - Homo sapiens constitutive androstane receptor SV14 (NR1I3) mRNA, partial cds, alternatively spliced. AY572820 - Homo sapiens constitutive androstane receptor SV15 (NR1I3) mRNA, partial cds, alternatively spliced. AY572821 - Homo sapiens constitutive androstane receptor SV16 (NR1I3) mRNA, partial cds, alternatively spliced. AY572822 - Homo sapiens constitutive androstane receptor SV17 (NR1I3) mRNA, complete cds, alternatively spliced. AY572823 - Homo sapiens constitutive androstane receptor SV18 (NR1I3) mRNA, complete cds, alternatively spliced. AY572824 - Homo sapiens constitutive androstane receptor SV19 (NR1I3) mRNA, complete cds, alternatively spliced. AY572825 - Homo sapiens constitutive androstane receptor SV20 (NR1I3) mRNA, complete cds, alternatively spliced. AY572826 - Homo sapiens constitutive androstane receptor SV21 (NR1I3) mRNA, complete cds, alternatively spliced. AY572827 - Homo sapiens constitutive androstane receptor SV22 (NR1I3) mRNA, complete cds, alternatively spliced. BC121120 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:150433 IMAGE:40120664), complete cds. BC121121 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:150434 IMAGE:40120665), complete cds. AB307702 - Homo sapiens NR1I3 mRNA for constitutive androstane receptor, complete cds. DQ022681 - Homo sapiens nuclear receptor subfamily 1, group I, member 3 mRNA, complete cds, alternatively spliced. HQ692838 - Homo sapiens constitutive androstane nuclear receptor variant 2 (NR1i3) mRNA, complete cds. HQ692839 - Homo sapiens constitutive androstane nuclear receptor variant 3 (NR1i3) mRNA, complete cds. HQ692840 - Homo sapiens constitutive androstane nuclear receptor variant 4 (NR1i3) mRNA, complete cds. HQ692841 - Homo sapiens constitutive androstane nuclear receptor variant 5 (NR1i3) mRNA, complete cds. HQ709178 - Homo sapiens constitutive androstane nuclear receptor (NR1I3) mRNA, complete cds. CU686946 - Synthetic construct Homo sapiens gateway clone IMAGE:100022636 5' read NR1I3 mRNA. AK303757 - Homo sapiens cDNA FLJ50348 complete cds, highly similar to Orphan nuclear receptor NR1I3. AK310773 - Homo sapiens cDNA, FLJ17815. AK316208 - Homo sapiens cDNA, FLJ79107 complete cds, highly similar to Orphan nuclear receptor NR1I3. AK303796 - Homo sapiens cDNA FLJ56764 complete cds, highly similar to Orphan nuclear receptor NR1I3. BC030972 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone IMAGE:4556554), with apparent retained intron.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity h_AcetaminophenPathway - Mechanism of Acetaminophen Activity and Toxicity