Human Gene RALGPS2 (uc010pnb.2)
Description: Homo sapiens Ral GEF with PH domain and SH3 binding motif 2 (RALGPS2), mRNA.Transcript (Including UTRs) Position: hg19 chr1:178,694,300-178,889,237 Size: 194,938 Total Exon Count: 19 Strand: +Coding Region Position: hg19 chr1:178,745,900-178,885,494 Size: 139,595 Coding Exon Count: 18
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: B7Z7B1_HUMAN DESCRIPTION: SubName: Full=cDNA FLJ61610, highly similar to Homo sapiens Ral GEF with PH domain and SH3 binding motif 2 (RALGPS2), transcript variant 2, mRNA;SIMILARITY: Contains 1 Ras-GEF domain.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RALGPS2
CDC HuGE Published Literature: RALGPS2
Positive Disease Associations: Insulin
Related Studies: Insulin 0 ]
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011993 - PH_like_domIPR001849 - Pleckstrin_homologyIPR008937 - Ras_GEFIPR023578 - Ras_GEF_domIPR001895 - RasGRF_CDC25Pfam Domains: PF00169 - PH domainPF00617 - RasGEF domainSCOP Domains: 48366 - Ras GEF50729 - PH domain-likeModBase Predicted Comparative 3D Structure on B7Z7B1 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BC047391 - Homo sapiens Ral GEF with PH domain and SH3 binding motif 2, mRNA (cDNA clone MGC:48311 IMAGE:5298449), complete cds.AK001106 - Homo sapiens cDNA FLJ10244 fis, clone HEMBB1000632, weakly similar to GUANINE NUCLEOTIDE RELEASING PROTEIN.AK301753 - Homo sapiens cDNA FLJ61610 complete cds, highly similar to Homo sapiens Ral GEF with PH domain and SH3 binding motif 2 (RALGPS2), transcript variant 2, mRNA.KJ894129 - Synthetic construct Homo sapiens clone ccsbBroadEn_03523 RALGPS2 gene, encodes complete protein.LF205410 - JP 2014500723-A/12913: Polycomb-Associated Non-Coding RNAs.JD142426 - Sequence 123450 from Patent EP1572962.MA440987 - JP 2018138019-A/12913: Polycomb-Associated Non-Coding RNAs.AK098470 - Homo sapiens cDNA FLJ25604 fis, clone JTH14207.JD391973 - Sequence 372997 from Patent EP1572962.BC045691 - Homo sapiens cDNA clone IMAGE:5301504.JD146608 - Sequence 127632 from Patent EP1572962.JD162352 - Sequence 143376 from Patent EP1572962.JD167748 - Sequence 148772 from Patent EP1572962.JD073324 - Sequence 54348 from Patent EP1572962.JD040387 - Sequence 21411 from Patent EP1572962.JD496874 - Sequence 477898 from Patent EP1572962.JD469529 - Sequence 450553 from Patent EP1572962.JD267900 - Sequence 248924 from Patent EP1572962.
Other Names for This Gene
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AK301753.1
exon count:
19 CDS single in 3' UTR:
no
RNA size:
2226 ORF size:
1674 CDS single in intron:
no
Alignment % ID:
99.95 txCdsPredict score:
3381.50 frame shift in genome:
no
% Coverage:
99.87 has start codon:
yes
stop codon in genome:
no
# of Alignments:
1 has end codon:
yes
retained intron:
no
# AT/AC introns
0 selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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