Human Gene ANGEL2 (uc010pto.2)
  Description: Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:213,165,524-213,188,820 Size: 23,297 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr1:213,168,383-213,184,556 Size: 16,174 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:213,165,524-213,188,820)mRNA (may differ from genome)Protein (418 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIPubMedTreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: F5H476_HUMAN
DESCRIPTION: SubName: Full=Protein angel homolog 2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.55 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 241.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -214.20574-0.373 Picture PostScript Text
3' UTR -789.732859-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005135 - Endo/exonuclease/phosphatase

Pfam Domains:
PF03372 - Endonuclease/Exonuclease/phosphatase family

SCOP Domains:
56219 - DNase I-like

ModBase Predicted Comparative 3D Structure on F5H476
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC047469 - Homo sapiens angel homolog 2 (Drosophila), mRNA (cDNA clone MGC:48353 IMAGE:5274835), complete cds.
AK022855 - Homo sapiens cDNA FLJ12793 fis, clone NT2RP2002033.
JD369221 - Sequence 350245 from Patent EP1572962.
JD384766 - Sequence 365790 from Patent EP1572962.
AF510741 - Homo sapiens chromosome 1 unknown mRNA.
JD311984 - Sequence 293008 from Patent EP1572962.
JD308040 - Sequence 289064 from Patent EP1572962.
JD435362 - Sequence 416386 from Patent EP1572962.
JD435363 - Sequence 416387 from Patent EP1572962.
JD308041 - Sequence 289065 from Patent EP1572962.
JD218504 - Sequence 199528 from Patent EP1572962.
JD522077 - Sequence 503101 from Patent EP1572962.
JD514196 - Sequence 495220 from Patent EP1572962.
JD514195 - Sequence 495219 from Patent EP1572962.
JD514197 - Sequence 495221 from Patent EP1572962.
AK093947 - Homo sapiens cDNA FLJ36628 fis, clone TRACH2017980.
AL079275 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 566443.
AK295116 - Homo sapiens cDNA FLJ56435 complete cds, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
AK299208 - Homo sapiens cDNA FLJ50627 complete cds, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
AK310946 - Homo sapiens cDNA, FLJ17988.
AK294479 - Homo sapiens cDNA FLJ50488 complete cds, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
AK299365 - Homo sapiens cDNA FLJ50631 complete cds, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
CU690426 - Synthetic construct Homo sapiens gateway clone IMAGE:100020832 5' read ANGEL2 mRNA.
KJ903551 - Synthetic construct Homo sapiens clone ccsbBroadEn_12945 ANGEL2 gene, encodes complete protein.
AK311276 - Homo sapiens cDNA, FLJ18318.
BC016966 - Homo sapiens angel homolog 2 (Drosophila), mRNA (cDNA clone IMAGE:4403747), complete cds.
AY468376 - Homo sapiens LOC90806-like mRNA, complete sequence.
KJ903550 - Synthetic construct Homo sapiens clone ccsbBroadEn_12944 ANGEL2 gene, encodes complete protein.
JD026137 - Sequence 7161 from Patent EP1572962.
JD034817 - Sequence 15841 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK299208, F5H476, F5H476_HUMAN
UCSC ID: uc010pto.2
RefSeq Accession: NM_144567
Protein: F5H476

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK299208.1
exon count: 9CDS single in 3' UTR: no RNA size: 1944
ORF size: 1257CDS single in intron: no Alignment % ID: 99.85
txCdsPredict score: 2426.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.