Description: Homo sapiens RNA binding motif protein 17 (RBM17), transcript variant 2, mRNA. RefSeq Summary (NM_001145547): This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]. Transcript (Including UTRs) Position: hg19 chr10:6,131,309-6,159,422 Size: 28,114 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr10:6,139,029-6,157,519 Size: 18,491 Coding Exon Count: 11
ID:SPF45_HUMAN DESCRIPTION: RecName: Full=Splicing factor 45; AltName: Full=45 kDa-splicing factor; AltName: Full=RNA-binding motif protein 17; FUNCTION: Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. SUBUNIT: Binds SXL. Associates with the spliceosome. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 1 G-patch domain. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96I25
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF542550 - Homo sapiens chromosome 10 map NT_033983.1 unknown mRNA. AK314952 - Homo sapiens cDNA, FLJ95864. BC007871 - Homo sapiens RNA binding motif protein 17, mRNA (cDNA clone MGC:14439 IMAGE:4303675), complete cds. BC039322 - Homo sapiens RNA binding motif protein 17, mRNA (cDNA clone MGC:43415 IMAGE:5267008), complete cds. JD128825 - Sequence 109849 from Patent EP1572962. JD221427 - Sequence 202451 from Patent EP1572962. JD495430 - Sequence 476454 from Patent EP1572962. JD264388 - Sequence 245412 from Patent EP1572962. JD420476 - Sequence 401500 from Patent EP1572962. JD163992 - Sequence 145016 from Patent EP1572962. JD398483 - Sequence 379507 from Patent EP1572962. JD398482 - Sequence 379506 from Patent EP1572962. JD396021 - Sequence 377045 from Patent EP1572962. JD235550 - Sequence 216574 from Patent EP1572962. JD453933 - Sequence 434957 from Patent EP1572962. CU675847 - Synthetic construct Homo sapiens gateway clone IMAGE:100017191 5' read RBM17 mRNA. AB528910 - Synthetic construct DNA, clone: pF1KE0688, Homo sapiens RBM17 gene for RNA binding motif protein 17, without stop codon, in Flexi system. HQ448221 - Synthetic construct Homo sapiens clone IMAGE:100071622; CCSB005200_01 RNA binding motif protein 17 (RBM17) gene, encodes complete protein. KJ899858 - Synthetic construct Homo sapiens clone ccsbBroadEn_09252 RBM17 gene, encodes complete protein. KJ904931 - Synthetic construct Homo sapiens clone ccsbBroadEn_14325 RBM17 gene, encodes complete protein. BC009064 - Homo sapiens RNA binding motif protein 17, mRNA (cDNA clone IMAGE:3868191), partial cds. JD351305 - Sequence 332329 from Patent EP1572962. JD501461 - Sequence 482485 from Patent EP1572962. BX648288 - Homo sapiens mRNA; cDNA DKFZp686F13131 (from clone DKFZp686F13131). FW340000 - Screening. AK021863 - Homo sapiens cDNA FLJ11801 fis, clone HEMBA1006253, weakly similar to DNA-DAMAGE-REPAIR/TOLERATION PROTEIN DRT111 PRECURSOR. JD137196 - Sequence 118220 from Patent EP1572962. JD087549 - Sequence 68573 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein Q96I25 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA