Human Gene DNHD1 (uc010rao.2)
  Description: Homo sapiens dynein heavy chain domain 1 (DNHD1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:6,587,471-6,593,254 Size: 5,784 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr11:6,587,614-6,593,216 Size: 5,603 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:6,587,471-6,593,254)mRNA (may differ from genome)Protein (1011 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DNHD1
CDC HuGE Published Literature: DNHD1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.15 RPKM in Testis
Total median expression: 117.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.50143-0.318 Picture PostScript Text
3' UTR -1.2038-0.032 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026983 - DHC_fam
IPR004273 - Dynein_heavy_dom

Pfam Domains:
PF03028 - Dynein heavy chain and region D6 of dynein motor

ModBase Predicted Comparative 3D Structure on Q9NSW8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003777 microtubule motor activity

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0030286 dynein complex


-  Descriptions from all associated GenBank mRNAs
  AB290171 - Homo sapiens mRNA for DNHD1 variant protein, partial cds.
AK128064 - Homo sapiens cDNA FLJ46184 fis, clone TESTI4004695.
AL834222 - Homo sapiens mRNA; cDNA DKFZp434K2212 (from clone DKFZp434K2212).
BC067363 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:6671688), with apparent retained intron.
BC082757 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:6585131).
AK057314 - Homo sapiens cDNA FLJ32752 fis, clone TESTI2001661, weakly similar to DYNEIN BETA CHAIN, FLAGELLAR OUTER ARM.
JD536754 - Sequence 517778 from Patent EP1572962.
JD549175 - Sequence 530199 from Patent EP1572962.
JD444620 - Sequence 425644 from Patent EP1572962.
JD466652 - Sequence 447676 from Patent EP1572962.
BC117301 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:40125852), complete cds.
BC117303 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:40125854), complete cds.
BC143910 - Homo sapiens cDNA clone IMAGE:9052428.
JD363421 - Sequence 344445 from Patent EP1572962.
JD374164 - Sequence 355188 from Patent EP1572962.
JD281025 - Sequence 262049 from Patent EP1572962.
JD524611 - Sequence 505635 from Patent EP1572962.
AL137690 - Homo sapiens mRNA; cDNA DKFZp434O032 (from clone DKFZp434O032).
AY358770 - Homo sapiens clone DNA129594 PVFW5781 (UNQ5781) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: BC143910, DKFZp434O032, Q9NSW8, Q9NSW8_HUMAN
UCSC ID: uc010rao.2
RefSeq Accession: NM_144666
Protein: Q9NSW8

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC143910.1
exon count: 10CDS single in 3' UTR: no RNA size: 3163
ORF size: 3036CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 6175.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.