Human Gene DEPDC7 (uc010reg.1)
  Description: Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:33,037,410-33,048,263 Size: 10,854 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr11:33,037,502-33,047,704 Size: 10,203 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:33,037,410-33,048,263)mRNA (may differ from genome)Protein (190 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.47 RPKM in Liver
Total median expression: 104.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.7092-0.366 Picture PostScript Text
3' UTR -173.79559-0.311 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000591 - DEP_dom
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00610 - Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on B4DH51
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  BC030970 - Homo sapiens DEP domain containing 7, mRNA (cDNA clone MGC:32600 IMAGE:4133262), complete cds.
AK294934 - Homo sapiens cDNA FLJ57926 complete cds, highly similar to Mus musculus DEP domain containing 7 (Depdc7), mRNA.
BC011446 - Homo sapiens DEP domain containing 7, mRNA (cDNA clone IMAGE:4073766), with apparent retained intron.
AJ245600 - Homo sapiens mRNA for hypothetical protein (TR2/D15 gene).
AK295960 - Homo sapiens cDNA FLJ60585 complete cds, highly similar to Mus musculus DEP domain containing 7 (Depdc7), mRNA.
EU446553 - Synthetic construct Homo sapiens clone IMAGE:100070002; IMAGE:100011762; FLH258263.01L DEP domain containing 7 (DEPDC7) gene, encodes complete protein.
CU689058 - Synthetic construct Homo sapiens gateway clone IMAGE:100022287 5' read DEPDC7 mRNA.
KJ899925 - Synthetic construct Homo sapiens clone ccsbBroadEn_09319 DEPDC7 gene, encodes complete protein.
AF447588 - Homo sapiens tissue-type testis unknown mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: AK294934, B4DH51, B4DH51_HUMAN, NM_001077242, NP_001070710
UCSC ID: uc010reg.1
RefSeq Accession: NM_001077242
Protein: B4DH51

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK294934.1
exon count: 2CDS single in 3' UTR: no RNA size: 1212
ORF size: 573CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1201.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 668# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.