Description: Homo sapiens olfactory receptor, family 6, subfamily Q, member 1 (OR6Q1), mRNA. RefSeq Summary (NM_001005186): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]. Sequence Note: This gene is a segregating pseudogene. This RefSeq represents the protein encoded by the reference genome allele, which is predicted to be functional according to the Classifier for Olfactory Receptor Pseudogenes. This RefSeq was derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. Transcript (Including UTRs) Position: hg19 chr11:57,798,425-57,799,378 Size: 954 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chr11:57,798,425-57,799,378 Size: 954 Coding Exon Count: 1
ID:OR6Q1_HUMAN DESCRIPTION: RecName: Full=Olfactory receptor 6Q1; AltName: Full=Olfactory receptor OR11-226; FUNCTION: Odorant receptor (Potential). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. POLYMORPHISM: A single nucleotide deletion at position Leu-229 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The deletion is more frequent in African-Americans than in non-Africans. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR6Q1";
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q8NGQ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007608 sensory perception of smell GO:0050896 response to stimulus GO:0050911 detection of chemical stimulus involved in sensory perception of smell
BC151147 - Homo sapiens olfactory receptor, family 6, subfamily Q, member 1, mRNA (cDNA clone MGC:168641 IMAGE:9021018), complete cds. BC151146 - Homo sapiens olfactory receptor, family 6, subfamily Q, member 1, mRNA (cDNA clone MGC:168640 IMAGE:9021017), complete cds.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04740 - Olfactory transduction
Reactome (by CSHL, EBI, and GO)
Protein Q8NGQ2 (Reactome details) participates in the following event(s):
US Server
