Human Gene FIBP (uc010ror.1)
  Description: Homo sapiens fibroblast growth factor (acidic) intracellular binding protein (FIBP), transcript variant 2, mRNA.
RefSeq Summary (NM_004214): Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr11:65,654,801-65,656,010 Size: 1,210 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr11:65,655,293-65,655,889 Size: 597 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:65,654,801-65,656,010)mRNA (may differ from genome)Protein (131 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMalacardsMGI
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FIBP
CDC HuGE Published Literature: FIBP

-  MalaCards Disease Associations
  MalaCards Gene Search: FIBP
Diseases sorted by gene-association score: thauvin-robinet-faivre syndrome* (920), renal dysplasia (9), coloboma (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 67.31 RPKM in Testis
Total median expression: 1511.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.80121-0.511 Picture PostScript Text
3' UTR -161.72492-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008614 - FIBP

Pfam Domains:
PF05427 - Acidic fibroblast growth factor binding (FIBP)

ModBase Predicted Comparative 3D Structure on B4DF10
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0017134 fibroblast growth factor binding


-  Descriptions from all associated GenBank mRNAs
  LF211166 - JP 2014500723-A/18669: Polycomb-Associated Non-Coding RNAs.
BC017448 - Homo sapiens fibroblast growth factor (acidic) intracellular binding protein, mRNA (cDNA clone MGC:15856 IMAGE:3509570), complete cds.
AK223438 - Homo sapiens mRNA for FGF intracellular binding protein isoform b variant, clone: FCC112C07.
AK289562 - Homo sapiens cDNA FLJ76995 complete cds, highly similar to Homo sapiens fibroblast growth factor (acidic) intracellular binding protein (FIBP), transcript variant 2, mRNA.
BC014388 - Homo sapiens fibroblast growth factor (acidic) intracellular binding protein, mRNA (cDNA clone MGC:856 IMAGE:3504921), complete cds.
AF171944 - Homo sapiens FIBP-1 mRNA, complete cds.
AF171945 - Homo sapiens FIBP-1 mRNA, complete cds.
AF171946 - Homo sapiens FIBP-1 mRNA, complete cds.
AF250391 - Homo sapiens aFGF intracellular binding protein (FIBP) mRNA, complete cds.
AF010187 - Homo sapiens FGF-1 intracellular binding protein (FIBP) mRNA, complete cds.
KJ892700 - Synthetic construct Homo sapiens clone ccsbBroadEn_02094 FIBP gene, encodes complete protein.
EU176427 - Synthetic construct Homo sapiens clone IMAGE:100006504; FLH193577.01X; RZPDo839H06252D fibroblast growth factor (acidic) intracellular binding protein (FIBP) gene, encodes complete protein.
EU176765 - Synthetic construct Homo sapiens clone IMAGE:100011536; FLH193573.01L; RZPDo839D02256D fibroblast growth factor (acidic) intracellular binding protein (FIBP) gene, encodes complete protein.
CR456749 - Homo sapiens full open reading frame cDNA clone RZPDo834A0811D for gene FIBP, fibroblast growth factor (acidic) intracellular binding protein; complete cds, incl. stopcodon.
AK309974 - Homo sapiens cDNA, FLJ17016.
AK296571 - Homo sapiens cDNA FLJ51235 complete cds, highly similar to Acidic fibroblast growth factorintracellular-binding protein.
AK315976 - Homo sapiens cDNA, FLJ78875 complete cds, highly similar to Acidic fibroblast growth factor intracellular-binding protein.
AK299159 - Homo sapiens cDNA FLJ60048 complete cds, highly similar to Acidic fibroblast growth factor intracellular-binding protein.
AK293882 - Homo sapiens cDNA FLJ59856 complete cds, moderately similar to Acidic fibroblast growth factor intracellular-binding protein.
JD029258 - Sequence 10282 from Patent EP1572962.
JD021502 - Sequence 2526 from Patent EP1572962.
MA446743 - JP 2018138019-A/18669: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK293882, B4DF10, B4DF10_HUMAN, NM_004214, NP_004205
UCSC ID: uc010ror.1
RefSeq Accession: NM_004214
Protein: B4DF10

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK293882.1
exon count: 2CDS single in 3' UTR: no RNA size: 923
ORF size: 396CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 939.00frame shift in genome: no % Coverage: 99.67
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.