Human Gene OLR1 (uc010sgz.1)
  Description: Homo sapiens oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 2, mRNA.
RefSeq Summary (NM_001172632): This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].
Transcript (Including UTRs)
   Position: hg19 chr12:10,310,899-10,320,198 Size: 9,300 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr12:10,312,615-10,319,422 Size: 6,808 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:10,310,899-10,320,198)mRNA (may differ from genome)Protein (77 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMalacardsMGIOMIMPubMed
TreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): OLR1
CDC HuGE Published Literature: OLR1
Positive Disease Associations: Alzheimer's Disease , Atherosclerosis , atherosclerosis, coronary , C-reactive protein cardiovascular event lipids , Edema rosiglitazone or pioglitazone , myocardial infarct , myocardial infarct; atherosclerosis, coronary , myocardial infarction
Related Studies:
  1. Alzheimer's Disease
    Luedecking-Zimmer, E. et al. 2002, Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12, Human genetics. 2002 Oct;111(5-Apr):443-51. [PubMed 12384789]
    Our data suggest that genetic variation in the OLR1 gene may modify the risk of AD in an APOE*4-dependent fashion.
  2. Alzheimer's Disease
    Lambert, J. C. et al. 2003, Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease., Journal of medical genetics. 2003 Jun;40(6):424-30. [PubMed 12807963]
    The OLR1 expression was significantly lower in AD cases bearing the CC and CT genotypes compared with controls with the same genotypes. In conclusion, our data suggest that genetic variation in the OLR1 gene may modify the risk of AD.
  3. Alzheimer's Disease
    D'Introno, A. et al. 2005, Polymorphisms in the oxidized low-density lipoprotein receptor-1 gene and risk of Alzheimer's disease., The journals of gerontology Series A, Biological sciences and medical sciences. 2005 Mar;60(3):280-4. [PubMed 15860461]
    In our population, the +1073 C/T OLR1 polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of OLR1 as a candidate risk gene for sporadic Alzheimer's disease.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: OLR1
Diseases sorted by gene-association score: myocardial infarction* (300), atherosclerosis (27), mental retardation, x-linked, snyder-robinson type (8), alzheimer disease (5), vascular disease (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.12 RPKM in Lung
Total median expression: 71.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.50156-0.215 Picture PostScript Text
3' UTR -412.641716-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on B7ZAN8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AB010710 - Homo sapiens mRNA for lectin-like oxidized LDL receptor, complete cds.
AX429248 - Sequence 3 from Patent WO0235236.
BC022295 - Homo sapiens oxidized low density lipoprotein (lectin-like) receptor 1, mRNA (cDNA clone MGC:22491 IMAGE:4722086), complete cds.
JD562053 - Sequence 543077 from Patent EP1572962.
JD263034 - Sequence 244058 from Patent EP1572962.
JD110656 - Sequence 91680 from Patent EP1572962.
AF035776 - Homo sapiens oxidized low-density lipoprotein receptor mRNA, complete cds.
JD091057 - Sequence 72081 from Patent EP1572962.
JD049311 - Sequence 30335 from Patent EP1572962.
JD549433 - Sequence 530457 from Patent EP1572962.
JD041874 - Sequence 22898 from Patent EP1572962.
JD113463 - Sequence 94487 from Patent EP1572962.
AK292124 - Homo sapiens cDNA FLJ75778 complete cds, highly similar to Homo sapiens oxidised low density lipoprotein (lectin-like) receptor 1 (OLR1), mRNA.
JD474314 - Sequence 455338 from Patent EP1572962.
AK308009 - Homo sapiens cDNA, FLJ97957.
JD556875 - Sequence 537899 from Patent EP1572962.
AK316353 - Homo sapiens cDNA, FLJ79252 complete cds, weakly similar to Oxidized low-density lipoprotein receptor 1.
JD241411 - Sequence 222435 from Patent EP1572962.
JD130690 - Sequence 111714 from Patent EP1572962.
AK295409 - Homo sapiens cDNA FLJ50964 complete cds, highly similar to Oxidized low-density lipoprotein receptor 1.
AK298040 - Homo sapiens cDNA FLJ52117 complete cds, highly similar to Oxidized low-density lipoprotein receptor 1.
AB102861 - Homo sapiens OLR1 mRNA for oxidised low density lipoprotein (lectin-like) receptor 1, complete cds.
CU692540 - Synthetic construct Homo sapiens gateway clone IMAGE:100022190 5' read OLR1 mRNA.
KJ891723 - Synthetic construct Homo sapiens clone ccsbBroadEn_01117 OLR1 gene, encodes complete protein.
KR711235 - Synthetic construct Homo sapiens clone CCSBHm_00021339 OLR1 (OLR1) mRNA, encodes complete protein.
DQ891409 - Synthetic construct clone IMAGE:100004039; FLH176655.01X; RZPDo839F10122D oxidised low density lipoprotein (lectin-like) receptor 1 (OLR1) gene, encodes complete protein.
DQ894585 - Synthetic construct Homo sapiens clone IMAGE:100009045; FLH176651.01L; RZPDo839F10121D oxidised low density lipoprotein (lectin-like) receptor 1 (OLR1) gene, encodes complete protein.
AB590414 - Synthetic construct DNA, clone: pFN21AE1554, Homo sapiens OLR1 gene for oxidized low density lipoprotein (lectin-like) receptor 1, without stop codon, in Flexi system.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03320 - PPAR signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: AK316353, B7ZAN8, B7ZAN8_HUMAN, NM_001172632, NP_001166103
UCSC ID: uc010sgz.1
RefSeq Accession: NM_001172632
Protein: B7ZAN8

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK316353.1
exon count: 4CDS single in 3' UTR: no RNA size: 822
ORF size: 234CDS single in intron: no Alignment % ID: 99.88
txCdsPredict score: 668.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.