Human Gene TUBA1C (uc010smh.1)
Description: Homo sapiens tubulin, alpha 1c (TUBA1C), mRNA.
Transcript (Including UTRs)
Position: hg19 chr12:49,621,709-49,667,113 Size: 45,405 Total Exon Count: 4 Strand: +
Coding Region
Position: hg19 chr12:49,621,737-49,667,010 Size: 45,274 Coding Exon Count: 4
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: F5H5D3_HUMAN
DESCRIPTION: SubName: Full=Tubulin alpha-1C chain;
FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).SUBUNIT: Dimer of alpha and beta chains (By similarity).SIMILARITY: Belongs to the tubulin family.CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002452 - Alpha_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR023123 - Tubulin_C
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase
Pfam Domains: PF00091 - Tubulin/FtsZ family, GTPase domain
PF03953 - Tubulin C-terminal domain
SCOP Domains: 52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like
ModBase Predicted Comparative 3D Structure on F5H5D3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK293589 - Homo sapiens cDNA FLJ55956 complete cds, highly similar to Tubulin alpha-6 chain.BC005946 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:14580 IMAGE:4134187), complete cds.AK223024 - Homo sapiens mRNA for tubulin alpha 6 variant, clone: JTH01540.BC011790 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:19827 IMAGE:4025017), complete cds.BC063036 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:64889 IMAGE:4397636), complete cds.BC004949 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:10851 IMAGE:3617714), complete cds.BC033064 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:45598 IMAGE:3926854), complete cds.BC051297 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:59688 IMAGE:3832363), complete cds.BC019298 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:4112 IMAGE:2905506), complete cds.BC021088 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:1754 IMAGE:3543481), complete cds.CU678818 - Synthetic construct Homo sapiens gateway clone IMAGE:100019456 5' read TUBA1C mRNA.CU676808 - Synthetic construct Homo sapiens gateway clone IMAGE:100017294 5' read TUBA1C mRNA.CU675203 - Synthetic construct Homo sapiens gateway clone IMAGE:100017296 5' read TUBA1C mRNA.DQ896235 - Synthetic construct Homo sapiens clone IMAGE:100010695; FLH191421.01L; RZPDo839D0167D tubulin, alpha 6 (TUBA6) gene, encodes complete protein.DQ892986 - Synthetic construct clone IMAGE:100005616; FLH191425.01X; RZPDo839D0177D tubulin, alpha 6 (TUBA6) gene, encodes complete protein.KJ899828 - Synthetic construct Homo sapiens clone ccsbBroadEn_09222 TUBA1C gene, encodes complete protein.KJ906372 - Synthetic construct Homo sapiens clone ccsbBroadEn_16042 TUBA1C gene, encodes complete protein.KJ906373 - Synthetic construct Homo sapiens clone ccsbBroadEn_16043 TUBA1C gene, encodes complete protein.JD034886 - Sequence 15910 from Patent EP1572962.DL492088 - Novel nucleic acids.DL490632 - Novel nucleic acids.JD035670 - Sequence 16694 from Patent EP1572962.JD032220 - Sequence 13244 from Patent EP1572962.DQ589802 - Homo sapiens piRNA piR-56914, complete sequence.JD024485 - Sequence 5509 from Patent EP1572962.JD027061 - Sequence 8085 from Patent EP1572962.JD035518 - Sequence 16542 from Patent EP1572962.JD029285 - Sequence 10309 from Patent EP1572962.JD029721 - Sequence 10745 from Patent EP1572962.JD033115 - Sequence 14139 from Patent EP1572962.JD027868 - Sequence 8892 from Patent EP1572962.JD060811 - Sequence 41835 from Patent EP1572962.JD545462 - Sequence 526486 from Patent EP1572962.JD220127 - Sequence 201151 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04540 - Gap junctionhsa05130 - Pathogenic Escherichia coli infection
Other Names for This Gene
Alternate Gene Symbols: AK293589, F5H5D3, F5H5D3_HUMAN, NM_032704, NP_116093UCSC ID: uc010smh.1RefSeq Accession: NM_032704
Protein: F5H5D3
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AK293589.1
exon count:
4 CDS single in 3' UTR:
no
RNA size:
1692
ORF size:
1560 CDS single in intron:
no
Alignment % ID:
99.82
txCdsPredict score:
2987.00 frame shift in genome:
no
% Coverage:
99.94
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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