Description: Homo sapiens Spi-C transcription factor (Spi-1/PU.1 related) (SPIC), mRNA. RefSeq Summary (NM_152323): The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]. Transcript (Including UTRs) Position: hg19 chr12:101,870,606-101,880,775 Size: 10,170 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr12:101,870,683-101,880,549 Size: 9,867 Coding Exon Count: 5
ID:SPIC_HUMAN DESCRIPTION: RecName: Full=Transcription factor Spi-C; FUNCTION: Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). SUBUNIT: Binds DNA as a monomer. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver. SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N5J4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001824 blastocyst development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0030154 cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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