Human Gene SVOP (uc010sxh.1)
Description: Homo sapiens SV2 related protein homolog (rat) (SVOP), mRNA.
Transcript (Including UTRs)
Position: hg19 chr12:109,304,658-109,458,845 Size: 154,188 Total Exon Count: 16 Strand: -
Coding Region
Position: hg19 chr12:109,306,311-109,458,673 Size: 152,363 Coding Exon Count: 16
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: SVOP_HUMAN
DESCRIPTION: RecName: Full=Synaptic vesicle 2-related protein; Short=SV2-related protein;
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity).SIMILARITY: Belongs to the major facilitator superfamily.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SVOP
CDC HuGE Published Literature: SVOP
Positive Disease Associations: Coronary Artery Disease
Related Studies: Coronary Artery Disease , , .
[PubMed 0 ]
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011701 - MFS
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR004749 - Orgcat_transp
IPR005828 - Sub_transporter
Pfam Domains: PF00083 - Sugar (and other) transporter
PF07690 - Major Facilitator Superfamily
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on Q8N4V2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC094722 - Homo sapiens SV2 related protein homolog (rat), mRNA (cDNA clone MGC:104529 IMAGE:4817829), complete cds.BC033587 - Homo sapiens SV2 related protein homolog (rat), mRNA (cDNA clone MGC:40088 IMAGE:5243017), complete cds.AK309780 - Homo sapiens cDNA, FLJ99821.KJ894208 - Synthetic construct Homo sapiens clone ccsbBroadEn_03602 SVOP gene, encodes complete protein.GQ129327 - Synthetic construct Homo sapiens clone HAIB:100068581; DKFZo008D0435 SV2 related protein homolog (rat) protein (SVOP) gene, complete cds.AB529106 - Synthetic construct DNA, clone: pF1KB4569, Homo sapiens SVOP gene for SV2 related protein homolog, without stop codon, in Flexi system.AL359592 - Homo sapiens mRNA; cDNA DKFZp761H039 (from clone DKFZp761H039).JD475213 - Sequence 456237 from Patent EP1572962.JD252816 - Sequence 233840 from Patent EP1572962.JD208275 - Sequence 189299 from Patent EP1572962.JD044606 - Sequence 25630 from Patent EP1572962.JD440074 - Sequence 421098 from Patent EP1572962.JD518603 - Sequence 499627 from Patent EP1572962.JD205664 - Sequence 186688 from Patent EP1572962.JD215860 - Sequence 196884 from Patent EP1572962.JD498214 - Sequence 479238 from Patent EP1572962.JD344035 - Sequence 325059 from Patent EP1572962.JD374275 - Sequence 355299 from Patent EP1572962.JD356539 - Sequence 337563 from Patent EP1572962.JD375842 - Sequence 356866 from Patent EP1572962.JD476872 - Sequence 457896 from Patent EP1572962.JD463160 - Sequence 444184 from Patent EP1572962.JD213196 - Sequence 194220 from Patent EP1572962.JD407617 - Sequence 388641 from Patent EP1572962.JD256806 - Sequence 237830 from Patent EP1572962.JD152290 - Sequence 133314 from Patent EP1572962.JD526333 - Sequence 507357 from Patent EP1572962.JD353021 - Sequence 334045 from Patent EP1572962.JD448675 - Sequence 429699 from Patent EP1572962.JD523039 - Sequence 504063 from Patent EP1572962.JD255522 - Sequence 236546 from Patent EP1572962.JD326795 - Sequence 307819 from Patent EP1572962.JD115721 - Sequence 96745 from Patent EP1572962.JD415313 - Sequence 396337 from Patent EP1572962.JD426860 - Sequence 407884 from Patent EP1572962.JD282664 - Sequence 263688 from Patent EP1572962.JD487374 - Sequence 468398 from Patent EP1572962.JD271533 - Sequence 252557 from Patent EP1572962.JD479626 - Sequence 460650 from Patent EP1572962.JD215373 - Sequence 196397 from Patent EP1572962.JD487803 - Sequence 468827 from Patent EP1572962.CU689662 - Synthetic construct Homo sapiens gateway clone IMAGE:100019836 5' read SVOP mRNA.
Other Names for This Gene
Alternate Gene Symbols: NM_018711, NP_061181, Q8N4V2, Q9NPW5, SVOP_HUMANUCSC ID: uc010sxh.1RefSeq Accession: NM_018711
Protein: Q8N4V2
(aka SVOP_HUMAN)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_018711.2
exon count:
15 CDS single in 3' UTR:
no
RNA size:
3486
ORF size:
1486 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3005.00 frame shift in genome:
yes
% Coverage:
94.95
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.