Human Gene ANKRD13A (uc010sxw.2)
  Description: Homo sapiens ankyrin repeat domain 13A (ANKRD13A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:110,437,235-110,477,235 Size: 40,001 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr12:110,437,494-110,475,359 Size: 37,866 Coding Exon Count: 15 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:110,437,235-110,477,235)mRNA (may differ from genome)Protein (589 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMalacardsMGI
OMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ANKRD13A
CDC HuGE Published Literature: ANKRD13A
Positive Disease Associations: Body Weights and Measures
Related Studies:
  1. Body Weights and Measures
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.

-  MalaCards Disease Associations
  MalaCards Gene Search: ANKRD13A
Diseases sorted by gene-association score: inclusion body myopathy with paget disease of bone and frontotemporal dementia (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.59 RPKM in Testis
Total median expression: 578.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -152.30259-0.588 Picture PostScript Text
3' UTR -572.281876-0.305 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021832 - ANKRD13
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR003903 - Ubiquitin-int_motif

Pfam Domains:
PF00023 - Ankyrin repeat
PF02809 - Ubiquitin interaction motif
PF11904 - GPCR-chaperone
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on B4DYP5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
 Protein Sequence  Protein Sequence 
 Alignment  Alignment 

-  Descriptions from all associated GenBank mRNAs
  AK308923 - Homo sapiens cDNA, FLJ98964.
BC057817 - Homo sapiens ankyrin repeat domain 13A, mRNA (cDNA clone IMAGE:30346590), with apparent retained intron.
AK025261 - Homo sapiens cDNA: FLJ21608 fis, clone COL07313, highly similar to AF155103 Homo sapiens NY-REN-25 antigen mRNA.
AF064604 - Homo sapiens KE03 protein mRNA, partial cds.
AK302535 - Homo sapiens cDNA FLJ54725 complete cds, highly similar to Ankyrin repeat domain-containing protein 13.
BC032833 - Homo sapiens ankyrin repeat domain 13A, mRNA (cDNA clone MGC:26764 IMAGE:4830174), complete cds.
JD151814 - Sequence 132838 from Patent EP1572962.
JD106759 - Sequence 87783 from Patent EP1572962.
CU691256 - Synthetic construct Homo sapiens gateway clone IMAGE:100022814 5' read ANKRD13A mRNA.
KJ903525 - Synthetic construct Homo sapiens clone ccsbBroadEn_12919 ANKRD13A gene, encodes complete protein.
AY364251 - Homo sapiens clone peg2085 NY-REN-25 antigen (ANKRD13) mRNA, complete cds.
AK293232 - Homo sapiens cDNA FLJ53297 complete cds, highly similar to Ankyrin repeat domain-containing protein 13.
AF155103 - Homo sapiens NY-REN-25 antigen mRNA, partial cds.
AK130522 - Homo sapiens cDNA FLJ27012 fis, clone SLV05358.
AK022658 - Homo sapiens cDNA FLJ12596 fis, clone NT2RM4001347, highly similar to Ankyrin repeat domain-containing protein 13.
AK095130 - Homo sapiens cDNA FLJ37811 fis, clone BRSSN2001869, moderately similar to Ankyrin repeat domain-containing protein 13.
JD503761 - Sequence 484785 from Patent EP1572962.
JD307338 - Sequence 288362 from Patent EP1572962.
JD323661 - Sequence 304685 from Patent EP1572962.
JD065983 - Sequence 47007 from Patent EP1572962.
JD155729 - Sequence 136753 from Patent EP1572962.
JD074356 - Sequence 55380 from Patent EP1572962.
JD191746 - Sequence 172770 from Patent EP1572962.
JD511034 - Sequence 492058 from Patent EP1572962.
JD535183 - Sequence 516207 from Patent EP1572962.
JD216142 - Sequence 197166 from Patent EP1572962.
JD471322 - Sequence 452346 from Patent EP1572962.
JD363962 - Sequence 344986 from Patent EP1572962.
JD509746 - Sequence 490770 from Patent EP1572962.
JD438742 - Sequence 419766 from Patent EP1572962.
DQ595076 - Homo sapiens piRNA piR-61188, complete sequence.
JD137329 - Sequence 118353 from Patent EP1572962.
JD356827 - Sequence 337851 from Patent EP1572962.
JD242177 - Sequence 223201 from Patent EP1572962.
JD203171 - Sequence 184195 from Patent EP1572962.
JD289533 - Sequence 270557 from Patent EP1572962.
JD245986 - Sequence 227010 from Patent EP1572962.
JD504984 - Sequence 486008 from Patent EP1572962.
JD185627 - Sequence 166651 from Patent EP1572962.
JD318282 - Sequence 299306 from Patent EP1572962.
JD384487 - Sequence 365511 from Patent EP1572962.
JD516178 - Sequence 497202 from Patent EP1572962.
JD500223 - Sequence 481247 from Patent EP1572962.
JD303118 - Sequence 284142 from Patent EP1572962.
JD260628 - Sequence 241652 from Patent EP1572962.
DQ570877 - Homo sapiens piRNA piR-30989, complete sequence.
JD549302 - Sequence 530326 from Patent EP1572962.
JD109406 - Sequence 90430 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK302535, B4DYP5, B4DYP5_HUMAN, NM_033121, NP_149112
UCSC ID: uc010sxw.2
RefSeq Accession: NM_033121
Protein: B4DYP5 CCDS: CCDS9140.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK302535.1
exon count: 15CDS single in 3' UTR: no RNA size: 1905
ORF size: 1770CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 3672.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.