Human Gene WBP4 (uc010tfd.2)
  Description: Homo sapiens WW domain binding protein 4 (WBP4), mRNA.
RefSeq Summary (NM_007187): This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr13:41,635,697-41,658,139 Size: 22,443 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr13:41,635,810-41,657,050 Size: 21,241 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:41,635,697-41,658,139)mRNA (may differ from genome)Protein (355 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.64 RPKM in Uterus
Total median expression: 512.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.10113-0.337 Picture PostScript Text
3' UTR -254.121089-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001202 - WW_Rsp5_WWP
IPR013085 - Znf_U1-C

Pfam Domains:
PF00397 - WW domain
PF06220 - U1 zinc finger

SCOP Domains:
51045 - WW domain
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on B7Z4M2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK000979 - Homo sapiens cDNA FLJ10117 fis, clone HEMBA1002810, highly similar to Homo sapiens formin binding protein 21 mRNA.
AK314525 - Homo sapiens cDNA, FLJ95344, highly similar to Homo sapiens WW domain binding protein 4 (formin binding protein 21) (WBP4), mRNA.
AK001557 - Homo sapiens cDNA FLJ10695 fis, clone NT2RP3000403, highly similar to WW domain-binding protein 4.
AK297536 - Homo sapiens cDNA FLJ52917 complete cds, highly similar to WW domain-binding protein 4.
BC108310 - Homo sapiens WW domain binding protein 4 (formin binding protein 21), mRNA (cDNA clone MGC:117310 IMAGE:6014541), complete cds.
AF071185 - Homo sapiens formin binding protein 21 mRNA, complete cds.
BC104879 - Homo sapiens WW domain binding protein 4 (formin binding protein 21), mRNA (cDNA clone MGC:132539 IMAGE:8143882), complete cds.
JD310533 - Sequence 291557 from Patent EP1572962.
AB385558 - Synthetic construct DNA, clone: pF1KB8002, Homo sapiens WBP4 gene for WW domain-binding protein 4, complete cds, without stop codon, in Flexi system.
KJ893250 - Synthetic construct Homo sapiens clone ccsbBroadEn_02644 WBP4 gene, encodes complete protein.
JD088589 - Sequence 69613 from Patent EP1572962.
JD563842 - Sequence 544866 from Patent EP1572962.
JD371396 - Sequence 352420 from Patent EP1572962.
JD433859 - Sequence 414883 from Patent EP1572962.
JD334082 - Sequence 315106 from Patent EP1572962.
JD168421 - Sequence 149445 from Patent EP1572962.
JD243001 - Sequence 224025 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK297536, B7Z4M2, B7Z4M2_HUMAN, NM_007187, NP_009118
UCSC ID: uc010tfd.2
RefSeq Accession: NM_007187
Protein: B7Z4M2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK297536.1
exon count: 9CDS single in 3' UTR: no RNA size: 1464
ORF size: 1068CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1676.00frame shift in genome: no % Coverage: 99.93
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.