Human Gene ZFYVE26 (uc010tta.2)
  Description: Homo sapiens zinc finger, FYVE domain containing 26 (ZFYVE26), mRNA.
RefSeq Summary (NM_015346): This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008].
Transcript (Including UTRs)
   Position: hg19 chr14:68,262,950-68,283,306 Size: 20,357 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr14:68,264,345-68,282,680 Size: 18,336 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:68,262,950-68,283,306)mRNA (may differ from genome)Protein (791 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZFYVE26
CDC HuGE Published Literature: ZFYVE26

-  MalaCards Disease Associations
  MalaCards Gene Search: ZFYVE26
Diseases sorted by gene-association score: spastic paraplegia 15, autosomal recessive* (1278), spastic paraplegia 15* (540), paraplegia (13), spastic paraplegia 49, autosomal recessive (12), spastic paraplegia 35, autosomal recessive (10), spastic paraplegia 39, autosomal recessive (8), vici syndrome (7), spastic paraplegia 48, autosomal recessive (7), hereditary spastic paraplegia (6), axonal neuropathy (5), charcot-marie-tooth disease, axonal, type 2s (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.48 RPKM in Brain - Cerebellum
Total median expression: 189.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.10139-0.375 Picture PostScript Text
3' UTR -599.611395-0.430 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q68DK2-4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Descriptions from all associated GenBank mRNAs
  CR749276 - Homo sapiens mRNA; cDNA DKFZp686F19106 (from clone DKFZp686F19106).
BX537886 - Homo sapiens mRNA; cDNA DKFZp686N044 (from clone DKFZp686N044).
AB425197 - Homo sapiens ZFYVE26 mRNA for FYVE domain containing 26 zinc finger variant protein.
BC144594 - Homo sapiens cDNA clone IMAGE:9053124.
BX538025 - Homo sapiens mRNA; cDNA DKFZp686F066 (from clone DKFZp686F066).
CR749365 - Homo sapiens mRNA; cDNA DKFZp781H1112 (from clone DKFZp781H1112).
BC172413 - Synthetic construct Homo sapiens clone IMAGE:100069107, MGC:199118 zinc finger, FYVE domain containing 26 (ZFYVE26) mRNA, encodes complete protein.
AB463379 - Synthetic construct DNA, clone: pF1KA0321, Homo sapiens ZFYVE26 gene for zinc finger, FYVE domain containing protein 26, without stop codon, in Flexi system.
BX648683 - Homo sapiens mRNA; cDNA DKFZp686O1168 (from clone DKFZp686O1168).
BX648036 - Homo sapiens mRNA; cDNA DKFZp686H2396 (from clone DKFZp686H2396).
JD308169 - Sequence 289193 from Patent EP1572962.
JD435463 - Sequence 416487 from Patent EP1572962.
JD289141 - Sequence 270165 from Patent EP1572962.
AK304428 - Homo sapiens cDNA FLJ50043 complete cds, highly similar to Homo sapiens zinc finger, FYVE domain containing 26 (ZFYVE26), mRNA.
AK308233 - Homo sapiens cDNA, FLJ98181.
JD336822 - Sequence 317846 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK304428, KIAA0321, NM_015346, NP_056161, Q68DK2-4
UCSC ID: uc010tta.2
RefSeq Accession: NM_015346
Protein: Q68DK2-4, splice isoform of Q68DK2

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene ZFYVE26:
hsp (Hereditary Spastic Paraplegia Overview)
spg15 (Spastic Paraplegia 15)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK304428.1
exon count: 12CDS single in 3' UTR: no RNA size: 2819
ORF size: 2376CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 4865.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 1439# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.