Description: Homo sapiens maternally expressed 3 (non-protein coding) (MEG3), transcript variant 13, non-coding RNA. RefSeq Summary (NR_046470): This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]. Transcript (Including UTRs) Position: hg19 chr14:101,292,445-101,327,360 Size: 34,916 Total Exon Count: 8 Strand: +
Diabetes Mellitus, Type 1 Chris Wallace et al. Nature genetics 2010, The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes., Nature genetics.
[PubMed 19966805]
type 1 diabetes Wallace ,et al. 2009, The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes, Nature genetics 2010 42- 1 : 68-71.
[PubMed 19966805]
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
LF205126 - JP 2014500723-A/12629: Polycomb-Associated Non-Coding RNAs. LF209649 - JP 2014500723-A/17152: Polycomb-Associated Non-Coding RNAs. GQ183494 - Homo sapiens MEG3 isoform b ncRNA, complete sequence, alternatively spliced. GQ183495 - Homo sapiens MEG3 isoform c ncRNA, complete sequence, alternatively spliced. GQ183496 - Homo sapiens MEG3 isoform d ncRNA, complete sequence, alternatively spliced. GQ183497 - Homo sapiens MEG3 isoform e ncRNA, complete sequence, alternatively spliced. GQ183498 - Homo sapiens MEG3 isoform f ncRNA, complete sequence, alternatively spliced. GQ183499 - Homo sapiens MEG3 isoform g ncRNA, complete sequence, alternatively spliced. GQ183500 - Homo sapiens MEG3 isoform h ncRNA, complete sequence, alternatively spliced. GQ183501 - Homo sapiens MEG3 isoform i ncRNA, complete sequence, alternatively spliced. GQ183502 - Homo sapiens MEG3 isoform j ncRNA, complete sequence, alternatively spliced. GQ183503 - Homo sapiens MEG3 isoform k ncRNA, complete sequence, alternatively spliced. AB032607 - Homo sapiens MEG3 mRNA, partial sequence, imprinted gene. BX247998 - human full-length cDNA clone CS0DM001YI13 of Fetal liver of Homo sapiens (human). BX161452 - human full-length cDNA clone CS0DI033YL14 of Placenta of Homo sapiens (human). BX248012 - human full-length cDNA clone CS0DM008YG24 of Fetal liver of Homo sapiens (human). AY314975 - Homo sapiens maternally expressed gene 3 (MEG3) mRNA, complete sequence. BX161432 - human full-length cDNA clone CS0DI010YL19 of Placenta of Homo sapiens (human). AK057522 - Homo sapiens cDNA FLJ32960 fis, clone TESTI2008240. BC036882 - Homo sapiens, clone IMAGE:5242371, mRNA. AK092504 - Homo sapiens cDNA FLJ35185 fis, clone PLACE6015636. AK127864 - Homo sapiens cDNA FLJ45967 fis, clone PLACE7016214. AK055725 - Homo sapiens cDNA FLJ31163 fis, clone KIDNE1000050. AF447875 - Homo sapiens FP504 mRNA, complete cds. AJ413186 - Homo sapiens mRNA for PREBP1 protein. AK092707 - Homo sapiens cDNA FLJ35388 fis, clone SKNMC1000137. BC062783 - Homo sapiens maternally expressed 3, mRNA (cDNA clone IMAGE:4719491). MA440703 - JP 2018138019-A/12629: Polycomb-Associated Non-Coding RNAs. MA445226 - JP 2018138019-A/17152: Polycomb-Associated Non-Coding RNAs. MB417757 - JP 2019518439-A/13: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417761 - JP 2019518439-A/17: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417763 - JP 2019518439-A/19: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417762 - JP 2019518439-A/18: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417760 - JP 2019518439-A/16: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417758 - JP 2019518439-A/14: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417759 - JP 2019518439-A/15: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MH929320 - Homo sapiens maternally expressed 3 transcript variant lncRNA (MEG3), complete sequence. BC023543 - Homo sapiens maternally expressed 3, mRNA (cDNA clone IMAGE:4130494), partial cds. BC051294 - Homo sapiens maternally expressed 3, mRNA (cDNA clone IMAGE:3627151), partial cds. LF330447 - JP 2014500723-A/137950: Polycomb-Associated Non-Coding RNAs. LF381137 - JP 2014500723-A/188640: Polycomb-Associated Non-Coding RNAs. LF381136 - JP 2014500723-A/188639: Polycomb-Associated Non-Coding RNAs. LF330454 - JP 2014500723-A/137957: Polycomb-Associated Non-Coding RNAs. LF330455 - JP 2014500723-A/137958: Polycomb-Associated Non-Coding RNAs. LF381135 - JP 2014500723-A/188638: Polycomb-Associated Non-Coding RNAs. AF052114 - Homo sapiens clone 23887 mRNA sequence. LF330456 - JP 2014500723-A/137959: Polycomb-Associated Non-Coding RNAs. LF381134 - JP 2014500723-A/188637: Polycomb-Associated Non-Coding RNAs. LF330457 - JP 2014500723-A/137960: Polycomb-Associated Non-Coding RNAs. LF381133 - JP 2014500723-A/188636: Polycomb-Associated Non-Coding RNAs. BC092509 - Homo sapiens maternally expressed 3, mRNA (cDNA clone IMAGE:4818803). LF330469 - JP 2014500723-A/137972: Polycomb-Associated Non-Coding RNAs. MA566024 - JP 2018138019-A/137950: Polycomb-Associated Non-Coding RNAs. MA566031 - JP 2018138019-A/137957: Polycomb-Associated Non-Coding RNAs. MA566032 - JP 2018138019-A/137958: Polycomb-Associated Non-Coding RNAs. MA566033 - JP 2018138019-A/137959: Polycomb-Associated Non-Coding RNAs. MA566034 - JP 2018138019-A/137960: Polycomb-Associated Non-Coding RNAs. MA566046 - JP 2018138019-A/137972: Polycomb-Associated Non-Coding RNAs. MA616714 - JP 2018138019-A/188640: Polycomb-Associated Non-Coding RNAs. MA616713 - JP 2018138019-A/188639: Polycomb-Associated Non-Coding RNAs. MA616712 - JP 2018138019-A/188638: Polycomb-Associated Non-Coding RNAs. MA616711 - JP 2018138019-A/188637: Polycomb-Associated Non-Coding RNAs. MA616710 - JP 2018138019-A/188636: Polycomb-Associated Non-Coding RNAs. MB417764 - JP 2019518439-A/20: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417753 - JP 2019518439-A/9: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417755 - JP 2019518439-A/11: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417754 - JP 2019518439-A/10: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. MB417756 - JP 2019518439-A/12: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling. AK124580 - Homo sapiens cDNA FLJ42589 fis, clone BRACE3009701. BC113096 - Homo sapiens cDNA clone IMAGE:40076172.