Human Gene MEG3 (uc010txf.2)
  Description: Homo sapiens maternally expressed 3 (non-protein coding) (MEG3), transcript variant 14, non-coding RNA.
RefSeq Summary (NR_046471): This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012].
Transcript (Including UTRs)
   Position: hg19 chr14:101,292,445-101,327,360 Size: 34,916 Total Exon Count: 6 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:101,292,445-101,327,360)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerH-INVHGNCLynx
MalacardsPubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MEG3
CDC HuGE Published Literature: MEG3
Positive Disease Associations: Diabetes Mellitus, Type 1 , type 1 diabetes
Related Studies:
  1. Diabetes Mellitus, Type 1
    Chris Wallace et al. Nature genetics 2010, The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes., Nature genetics. [PubMed 19966805]
  2. type 1 diabetes
    Wallace ,et al. 2009, The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes, Nature genetics 2010 42- 1 : 68-71. [PubMed 19966805]

-  MalaCards Disease Associations
  MalaCards Gene Search: MEG3
Diseases sorted by gene-association score: kagami-ogata syndrome* (301), paternal 14q32.2 microdeletion syndrome* (18), maternal 14q32.2 microdeletion syndrome* (18), maternal 14q32.2 hypermethylation syndrome* (18), paternal 14q32.2 hypomethylation syndrome* (18), temple syndrome* (14), silver-russell syndrome (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 216.46 RPKM in Pituitary
Total median expression: 1395.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF205126 - JP 2014500723-A/12629: Polycomb-Associated Non-Coding RNAs.
LF209649 - JP 2014500723-A/17152: Polycomb-Associated Non-Coding RNAs.
GQ183494 - Homo sapiens MEG3 isoform b ncRNA, complete sequence, alternatively spliced.
GQ183495 - Homo sapiens MEG3 isoform c ncRNA, complete sequence, alternatively spliced.
GQ183496 - Homo sapiens MEG3 isoform d ncRNA, complete sequence, alternatively spliced.
GQ183497 - Homo sapiens MEG3 isoform e ncRNA, complete sequence, alternatively spliced.
GQ183498 - Homo sapiens MEG3 isoform f ncRNA, complete sequence, alternatively spliced.
GQ183499 - Homo sapiens MEG3 isoform g ncRNA, complete sequence, alternatively spliced.
GQ183500 - Homo sapiens MEG3 isoform h ncRNA, complete sequence, alternatively spliced.
GQ183501 - Homo sapiens MEG3 isoform i ncRNA, complete sequence, alternatively spliced.
GQ183502 - Homo sapiens MEG3 isoform j ncRNA, complete sequence, alternatively spliced.
GQ183503 - Homo sapiens MEG3 isoform k ncRNA, complete sequence, alternatively spliced.
AB032607 - Homo sapiens MEG3 mRNA, partial sequence, imprinted gene.
BX247998 - human full-length cDNA clone CS0DM001YI13 of Fetal liver of Homo sapiens (human).
BX161452 - human full-length cDNA clone CS0DI033YL14 of Placenta of Homo sapiens (human).
BX248012 - human full-length cDNA clone CS0DM008YG24 of Fetal liver of Homo sapiens (human).
AY314975 - Homo sapiens maternally expressed gene 3 (MEG3) mRNA, complete sequence.
BX161432 - human full-length cDNA clone CS0DI010YL19 of Placenta of Homo sapiens (human).
AK057522 - Homo sapiens cDNA FLJ32960 fis, clone TESTI2008240.
BC036882 - Homo sapiens, clone IMAGE:5242371, mRNA.
AK092504 - Homo sapiens cDNA FLJ35185 fis, clone PLACE6015636.
AK127864 - Homo sapiens cDNA FLJ45967 fis, clone PLACE7016214.
AK055725 - Homo sapiens cDNA FLJ31163 fis, clone KIDNE1000050.
AF447875 - Homo sapiens FP504 mRNA, complete cds.
AJ413186 - Homo sapiens mRNA for PREBP1 protein.
AK092707 - Homo sapiens cDNA FLJ35388 fis, clone SKNMC1000137.
BC062783 - Homo sapiens maternally expressed 3, mRNA (cDNA clone IMAGE:4719491).
MA440703 - JP 2018138019-A/12629: Polycomb-Associated Non-Coding RNAs.
MA445226 - JP 2018138019-A/17152: Polycomb-Associated Non-Coding RNAs.
MB417757 - JP 2019518439-A/13: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417761 - JP 2019518439-A/17: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417763 - JP 2019518439-A/19: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417762 - JP 2019518439-A/18: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417760 - JP 2019518439-A/16: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417758 - JP 2019518439-A/14: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417759 - JP 2019518439-A/15: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MH929320 - Homo sapiens maternally expressed 3 transcript variant lncRNA (MEG3), complete sequence.
BC023543 - Homo sapiens maternally expressed 3, mRNA (cDNA clone IMAGE:4130494), partial cds.
BC051294 - Homo sapiens maternally expressed 3, mRNA (cDNA clone IMAGE:3627151), partial cds.
LF330447 - JP 2014500723-A/137950: Polycomb-Associated Non-Coding RNAs.
LF381137 - JP 2014500723-A/188640: Polycomb-Associated Non-Coding RNAs.
LF381136 - JP 2014500723-A/188639: Polycomb-Associated Non-Coding RNAs.
LF330454 - JP 2014500723-A/137957: Polycomb-Associated Non-Coding RNAs.
LF330455 - JP 2014500723-A/137958: Polycomb-Associated Non-Coding RNAs.
LF381135 - JP 2014500723-A/188638: Polycomb-Associated Non-Coding RNAs.
AF052114 - Homo sapiens clone 23887 mRNA sequence.
LF330456 - JP 2014500723-A/137959: Polycomb-Associated Non-Coding RNAs.
LF381134 - JP 2014500723-A/188637: Polycomb-Associated Non-Coding RNAs.
LF330457 - JP 2014500723-A/137960: Polycomb-Associated Non-Coding RNAs.
LF381133 - JP 2014500723-A/188636: Polycomb-Associated Non-Coding RNAs.
BC092509 - Homo sapiens maternally expressed 3, mRNA (cDNA clone IMAGE:4818803).
MA566024 - JP 2018138019-A/137950: Polycomb-Associated Non-Coding RNAs.
MA566031 - JP 2018138019-A/137957: Polycomb-Associated Non-Coding RNAs.
MA566032 - JP 2018138019-A/137958: Polycomb-Associated Non-Coding RNAs.
MA566033 - JP 2018138019-A/137959: Polycomb-Associated Non-Coding RNAs.
MA566034 - JP 2018138019-A/137960: Polycomb-Associated Non-Coding RNAs.
MA616714 - JP 2018138019-A/188640: Polycomb-Associated Non-Coding RNAs.
MA616713 - JP 2018138019-A/188639: Polycomb-Associated Non-Coding RNAs.
MA616712 - JP 2018138019-A/188638: Polycomb-Associated Non-Coding RNAs.
MA616711 - JP 2018138019-A/188637: Polycomb-Associated Non-Coding RNAs.
MA616710 - JP 2018138019-A/188636: Polycomb-Associated Non-Coding RNAs.
MB417764 - JP 2019518439-A/20: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417753 - JP 2019518439-A/9: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417755 - JP 2019518439-A/11: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417754 - JP 2019518439-A/10: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
MB417756 - JP 2019518439-A/12: The lncRNA Meg3 for therapy and diagnosis of cardiac remodelling.
AK124580 - Homo sapiens cDNA FLJ42589 fis, clone BRACE3009701.
BC113096 - Homo sapiens cDNA clone IMAGE:40076172.

-  Other Names for This Gene
  Alternate Gene Symbols: NR_046471
UCSC ID: uc010txf.2
RefSeq Accession: NR_046471

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: NR_046471.1
exon count: 6CDS single in 3' UTR: no RNA size: 1547
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 246.00frame shift in genome: no % Coverage: 98.00
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.