Human Gene FAM214A (uc010ugf.2)
  Description: Homo sapiens family with sequence similarity 214, member A (FAM214A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:52,873,518-52,944,237 Size: 70,720 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr15:52,874,351-52,944,103 Size: 69,753 Coding Exon Count: 12 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:52,873,518-52,944,237)mRNA (may differ from genome)Protein (1083 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C006780 bisphenol A
  • C569670 1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D000393 Air Pollutants
  • D017638 Asbestos, Crocidolite
  • D001564 Benzo(a)pyrene
  • D019327 Copper Sulfate
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.44 RPKM in Breast - Mammary Tissue
Total median expression: 381.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.50134-0.280 Picture PostScript Text
3' UTR -176.54833-0.212 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF13889 - Chromosome segregation during meiosis
PF13915 - Domain of unknown function (DUF4210)

ModBase Predicted Comparative 3D Structure on Q32MH5-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC040548 - Homo sapiens KIAA1370, mRNA (cDNA clone MGC:39759 IMAGE:5288206), complete cds.
AB037791 - Homo sapiens KIAA1370 mRNA for KIAA1370 protein.
AK292917 - Homo sapiens cDNA FLJ77246 complete cds.
BC109128 - Homo sapiens KIAA1370, mRNA (cDNA clone MGC:126495 IMAGE:40036502), complete cds.
BC109127 - Homo sapiens KIAA1370, mRNA (cDNA clone MGC:126494 IMAGE:40036501), complete cds.
AK308049 - Homo sapiens cDNA, FLJ97997.
AL832519 - Homo sapiens mRNA; cDNA DKFZp666F111 (from clone DKFZp666F111).
BC058839 - Homo sapiens KIAA1370, mRNA (cDNA clone IMAGE:6619439), partial cds.
BC073908 - Homo sapiens KIAA1370, mRNA (cDNA clone IMAGE:4514046), partial cds.
AK001842 - Homo sapiens cDNA FLJ10980 fis, clone PLACE1001570.
JD314435 - Sequence 295459 from Patent EP1572962.
BC083498 - Homo sapiens KIAA1370, mRNA (cDNA clone IMAGE:4801842), partial cds.
AK293920 - Homo sapiens cDNA FLJ59489 complete cds.
JD501087 - Sequence 482111 from Patent EP1572962.
JD491057 - Sequence 472081 from Patent EP1572962.
JD055473 - Sequence 36497 from Patent EP1572962.
AB463086 - Synthetic construct DNA, clone: pF1KA1370, Homo sapiens KIAA1370 gene, without stop codon, in Flexi system.
AK293730 - Homo sapiens cDNA FLJ54413 complete cds.
AK308855 - Homo sapiens cDNA, FLJ98896.

-  Other Names for This Gene
  Alternate Gene Symbols: AK293920, KIAA1370, NM_019600, NP_062546, Q32MH5-3
UCSC ID: uc010ugf.2
RefSeq Accession: NM_019600
Protein: Q32MH5-3, splice isoform of Q32MH5 CCDS: CCDS45263.1, CCDS66773.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK293920.1
exon count: 12CDS single in 3' UTR: no RNA size: 3687
ORF size: 3252CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 6701.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.