Description: Homo sapiens protein regulator of cytokinesis 1 (PRC1), transcript variant 2, mRNA. RefSeq Summary (NM_199413): This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. Transcript (Including UTRs) Position: hg19 chr15:91,524,173-91,537,881 Size: 13,709 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr15:91,524,702-91,527,358 Size: 2,657 Coding Exon Count: 3
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PRC1 CDC HuGE Published Literature: PRC1 Positive Disease Associations: Diabetes Mellitus, Type 2 Related Studies:
Diabetes Mellitus, Type 2 Benjamin F Voight et al. Nature genetics 2010, Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis., Nature genetics.
[PubMed 20581827]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03999 - Microtubule associated protein (MAP65/ASE1 family)
ModBase Predicted Comparative 3D Structure on B4E238
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary