Human Gene MON1B (uc010vnf.2)
  Description: Homo sapiens MON1 homolog B (yeast) (MON1B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:77,224,836-77,233,543 Size: 8,708 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr16:77,225,383-77,232,205 Size: 6,823 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:77,224,836-77,233,543)mRNA (may differ from genome)Protein (438 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: E7EW32_HUMAN
DESCRIPTION: SubName: Full=Vacuolar fusion protein MON1 homolog B;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MON1B
CDC HuGE Published Literature: MON1B

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.85 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 294.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -141.70330-0.429 Picture PostScript Text
3' UTR -477.741338-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004353 - Vacuolar_fusion_protein_MON1

Pfam Domains:
PF03164 - Trafficking protein Mon1

ModBase Predicted Comparative 3D Structure on E7EW32
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC024277 - Homo sapiens MON1 homolog B (yeast), mRNA (cDNA clone MGC:39186 IMAGE:4843859), complete cds.
AK023374 - Homo sapiens cDNA FLJ13312 fis, clone OVARC1001480, moderately similar to Vacuolar fusion protein MON1 homolog B.
AK023896 - Homo sapiens cDNA FLJ13834 fis, clone THYRO1000684, highly similar to Homo sapiens MON1 homolog B (MON1B), mRNA.
AK296467 - Homo sapiens cDNA FLJ58007 complete cds, highly similar to Homo sapiens MON1 homolog B (MON1B), mRNA.
AK293392 - Homo sapiens cDNA FLJ58793 complete cds, highly similar to Homo sapiens MON1 homolog B (MON1B), mRNA.
AB020679 - Homo sapiens KIAA0872 mRNA for KIAA0872 protein.
AF442486 - Homo sapiens HSV-I stimulating-related protein (HSRG1) mRNA, complete cds.
JD369541 - Sequence 350565 from Patent EP1572962.
AB463127 - Synthetic construct DNA, clone: pF1KA0872, Homo sapiens MON1B gene for MON1 homolog B, without stop codon, in Flexi system.
KJ898416 - Synthetic construct Homo sapiens clone ccsbBroadEn_07810 MON1B gene, encodes complete protein.
DQ575388 - Homo sapiens piRNA piR-43500, complete sequence.
AK128411 - Homo sapiens cDNA FLJ46554 fis, clone THYMU3038970.
JD432972 - Sequence 413996 from Patent EP1572962.
JD203115 - Sequence 184139 from Patent EP1572962.
JD090690 - Sequence 71714 from Patent EP1572962.
JD549116 - Sequence 530140 from Patent EP1572962.
JD484346 - Sequence 465370 from Patent EP1572962.
JD482831 - Sequence 463855 from Patent EP1572962.
JD473300 - Sequence 454324 from Patent EP1572962.
JD351318 - Sequence 332342 from Patent EP1572962.
JD521366 - Sequence 502390 from Patent EP1572962.
JD376665 - Sequence 357689 from Patent EP1572962.
JD146575 - Sequence 127599 from Patent EP1572962.
JD192597 - Sequence 173621 from Patent EP1572962.
JD392563 - Sequence 373587 from Patent EP1572962.
JD057925 - Sequence 38949 from Patent EP1572962.
JD302432 - Sequence 283456 from Patent EP1572962.
JD376125 - Sequence 357149 from Patent EP1572962.
JD285650 - Sequence 266674 from Patent EP1572962.
JD193209 - Sequence 174233 from Patent EP1572962.
JD280296 - Sequence 261320 from Patent EP1572962.
JD321869 - Sequence 302893 from Patent EP1572962.
JD456846 - Sequence 437870 from Patent EP1572962.
JD461776 - Sequence 442800 from Patent EP1572962.
JD199389 - Sequence 180413 from Patent EP1572962.
JD243519 - Sequence 224543 from Patent EP1572962.
JD362759 - Sequence 343783 from Patent EP1572962.
JD347160 - Sequence 328184 from Patent EP1572962.
JD534914 - Sequence 515938 from Patent EP1572962.
JD290287 - Sequence 271311 from Patent EP1572962.
JD525061 - Sequence 506085 from Patent EP1572962.
JD040981 - Sequence 22005 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK296467, E7EW32, E7EW32_HUMAN, NM_014940, NP_055755
UCSC ID: uc010vnf.2
RefSeq Accession: NM_014940
Protein: E7EW32 CCDS: CCDS67083.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK296467.1
exon count: 5CDS single in 3' UTR: no RNA size: 1759
ORF size: 1317CDS single in intron: no Alignment % ID: 99.72
txCdsPredict score: 2744.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.