Description: Homo sapiens phospholipase D2 (PLD2), transcript variant 2, mRNA. RefSeq Summary (NM_001243108): The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]. Transcript (Including UTRs) Position: hg19 chr17:4,710,396-4,721,680 Size: 11,285 Total Exon Count: 18 Strand: + Coding Region Position: hg19 chr17:4,712,441-4,721,407 Size: 8,967 Coding Exon Count: 14
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PLD2 CDC HuGE Published Literature: PLD2 Positive Disease Associations: colorectal cancer Related Studies:
colorectal cancer Yamada, Y. et al. 2003, Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer., Journal of molecular medicine (Berlin, Germany). 2003 Feb;81(2):126-31.
[PubMed 12601529]
These results suggest that the phospholipase D(2) gene is a susceptibility locus for colorectal cancer in Japanese individuals, although a functional effect of the 1814C-->T (Thr577Ile) polymorphism was not detected.
Colorectal Cancer Yamada Y 2003, Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer., Journal of molecular medicine (Berlin, Germany). 2003 Feb;81(2):126-31.
[PubMed 12601529]
These results suggest that the phospholipase D(2) gene is a susceptibility locus for colorectal cancer in Japanese individuals, although a functional effect of the 1814C-->T (Thr577Ile) polymorphism was not detected.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B7Z905
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
