Description: Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B), mRNA. RefSeq Summary (NM_012452): The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:16,832,849-16,875,402 Size: 42,554 Total Exon Count: 11 Strand: -
aneurysm, intracranial Inoue, K. et al. 2006, Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm. A Preliminary Study, Circulation 2006.
[PubMed 16618819]
We propose that TNFRSF13B is one of the susceptibility genes for IA.
Blood Proteins Yoichiro Kamatani et al. Nature genetics 2010, Genome-wide association study of hematological and biochemical traits in a Japanese population., Nature genetics.
[PubMed 20139978]
Blood Proteins Wael Osman et al. PloS one 2012, Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese., PloS one.
[PubMed 22558069]
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK024458 - Homo sapiens mRNA for FLJ00050 protein, partial cds. BC128223 - Homo sapiens TBC1 domain family, member 27, mRNA (cDNA clone IMAGE:40114556), with apparent retained intron. AK303298 - Homo sapiens cDNA FLJ52819 complete cds, highly similar to Tumor necrosis factor receptor superfamilymember 13B. JD364467 - Sequence 345491 from Patent EP1572962. JD364466 - Sequence 345490 from Patent EP1572962. JD513293 - Sequence 494317 from Patent EP1572962. JD413048 - Sequence 394072 from Patent EP1572962. JD451466 - Sequence 432490 from Patent EP1572962. JD139761 - Sequence 120785 from Patent EP1572962. JD522706 - Sequence 503730 from Patent EP1572962. JD351530 - Sequence 332554 from Patent EP1572962. JD448156 - Sequence 429180 from Patent EP1572962. JD332200 - Sequence 313224 from Patent EP1572962. JD308863 - Sequence 289887 from Patent EP1572962. JD334174 - Sequence 315198 from Patent EP1572962. JD388570 - Sequence 369594 from Patent EP1572962. JD321196 - Sequence 302220 from Patent EP1572962. JD041450 - Sequence 22474 from Patent EP1572962. JD169437 - Sequence 150461 from Patent EP1572962. JD529282 - Sequence 510306 from Patent EP1572962. JD557423 - Sequence 538447 from Patent EP1572962. JD430246 - Sequence 411270 from Patent EP1572962. JD118728 - Sequence 99752 from Patent EP1572962. JD388569 - Sequence 369593 from Patent EP1572962. JD273599 - Sequence 254623 from Patent EP1572962. JD559682 - Sequence 540706 from Patent EP1572962. JD092518 - Sequence 73542 from Patent EP1572962. JD169436 - Sequence 150460 from Patent EP1572962. JD410210 - Sequence 391234 from Patent EP1572962. JD443796 - Sequence 424820 from Patent EP1572962. JD400657 - Sequence 381681 from Patent EP1572962. JD265851 - Sequence 246875 from Patent EP1572962. JD357537 - Sequence 338561 from Patent EP1572962. JD426162 - Sequence 407186 from Patent EP1572962. JD510867 - Sequence 491891 from Patent EP1572962. KJ903615 - Synthetic construct Homo sapiens clone ccsbBroadEn_13009 TBC1D27 gene, encodes complete protein. JD394751 - Sequence 375775 from Patent EP1572962. JD216798 - Sequence 197822 from Patent EP1572962. JD118402 - Sequence 99426 from Patent EP1572962. JD377111 - Sequence 358135 from Patent EP1572962. JD228351 - Sequence 209375 from Patent EP1572962. JD219735 - Sequence 200759 from Patent EP1572962. JD116297 - Sequence 97321 from Patent EP1572962. JD253860 - Sequence 234884 from Patent EP1572962. JD037154 - Sequence 18178 from Patent EP1572962. AX772740 - Sequence 1 from Patent WO03045421. AF023614 - Homo sapiens transmembrane activator and CAML interactor (TACI) mRNA, complete cds. AX766384 - Sequence 1 from Patent WO03041730. AK097261 - Homo sapiens cDNA FLJ39942 fis, clone SPLEN2023024, highly similar to Macaca mulatta transmembrane activator (NF-AT) mRNA. AK223453 - Homo sapiens mRNA for tumor necrosis factor receptor 13B variant, clone: FCC114F06. BC109392 - Homo sapiens tumor necrosis factor receptor superfamily, member 13B, mRNA (cDNA clone MGC:133214 IMAGE:40030781), complete cds. AY302137 - Homo sapiens transmembrane activator and CAML interactor (TNFRSF13B) mRNA, complete cds; alternatively spliced. AK313302 - Homo sapiens cDNA, FLJ93815, highly similar to Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B), mRNA. KJ902345 - Synthetic construct Homo sapiens clone ccsbBroadEn_11739 TNFRSF13B gene, encodes complete protein. KR711554 - Synthetic construct Homo sapiens clone CCSBHm_00025940 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR711555 - Synthetic construct Homo sapiens clone CCSBHm_00025943 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR711556 - Synthetic construct Homo sapiens clone CCSBHm_00025946 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR711557 - Synthetic construct Homo sapiens clone CCSBHm_00025951 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR712223 - Synthetic construct Homo sapiens clone CCSBHm_00900178 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR712231 - Synthetic construct Homo sapiens clone CCSBHm_00900189 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR712232 - Synthetic construct Homo sapiens clone CCSBHm_00900190 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. AK301032 - Homo sapiens cDNA FLJ52770 complete cds, highly similar to Tumor necrosis factor receptor superfamily member 13B.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04672 - Intestinal immune network for IgA production hsa05340 - Primary immunodeficiency