Description: Homo sapiens cytochrome P450, family 4, subfamily F, polypeptide 3 (CYP4F3), transcript variant 3, mRNA. RefSeq Summary (NM_001199209): This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019]. Transcript (Including UTRs) Position: hg19 chr19:15,751,707-15,771,570 Size: 19,864 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr19:15,752,226-15,770,195 Size: 17,970 Coding Exon Count: 12
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B7Z8Z3
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK316136 - Homo sapiens cDNA, FLJ79035 complete cds, highly similar to Cytochrome P450 4F2 (EC 1.14.13.30). AK296802 - Homo sapiens cDNA FLJ50565 complete cds, highly similar to Cytochrome P450 4F3 (EC 1.14.13.30). AK298675 - Homo sapiens cDNA FLJ56125 complete cds, highly similar to Cytochrome P450 4F3 (EC 1.14.13.30). AK296761 - Homo sapiens cDNA FLJ56100 complete cds, highly similar to Cytochrome P450 4F2 (EC 1.14.13.30). LF384394 - JP 2014500723-A/191897: Polycomb-Associated Non-Coding RNAs. AB002454 - Homo sapiens mRNA for leukotriene B4 omega-hydroxylase, complete cds. JD436020 - Sequence 417044 from Patent EP1572962. JD042766 - Sequence 23790 from Patent EP1572962. AK304200 - Homo sapiens cDNA FLJ52393 complete cds, highly similar to Cytochrome P450 4F2 (EC 1.14.13.30). BC136299 - Homo sapiens cytochrome P450, family 4, subfamily F, polypeptide 3, mRNA (cDNA clone MGC:167909 IMAGE:9020286), complete cds. D12620 - Homo sapiens mRNA for cytochrome P-450LTBV, complete cds. D12621 - Homo sapiens mRNA for cytochrome P-450LTBV, partial cds, clone:S-8. AF054821 - Homo sapiens cytochrome P-450 mRNA, complete cds. JD341276 - Sequence 322300 from Patent EP1572962. AK303477 - Homo sapiens cDNA FLJ50432 complete cds, highly similar to Cytochrome P450 4F3 (EC 1.14.13.30). JD439877 - Sequence 420901 from Patent EP1572962. JD091802 - Sequence 72826 from Patent EP1572962. JD558185 - Sequence 539209 from Patent EP1572962. JD441031 - Sequence 422055 from Patent EP1572962. JD412063 - Sequence 393087 from Patent EP1572962. JD306073 - Sequence 287097 from Patent EP1572962. JD276595 - Sequence 257619 from Patent EP1572962. JD283083 - Sequence 264107 from Patent EP1572962. JD096710 - Sequence 77734 from Patent EP1572962. JD037844 - Sequence 18868 from Patent EP1572962. JD042833 - Sequence 23857 from Patent EP1572962. JD298872 - Sequence 279896 from Patent EP1572962. JD563973 - Sequence 544997 from Patent EP1572962. JD350398 - Sequence 331422 from Patent EP1572962. JD324726 - Sequence 305750 from Patent EP1572962. JD359328 - Sequence 340352 from Patent EP1572962. JD146148 - Sequence 127172 from Patent EP1572962. JD381372 - Sequence 362396 from Patent EP1572962. JD063611 - Sequence 44635 from Patent EP1572962. MA619971 - JP 2018138019-A/191897: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00590 - Arachidonic acid metabolism hsa01100 - Metabolic pathways