Description: Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA. RefSeq Summary (NM_006297): The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:44,047,464-44,079,730 Size: 32,267 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr19:44,047,544-44,079,610 Size: 32,067 Coding Exon Count: 16
ID:F5H8D7_HUMAN DESCRIPTION: SubName: Full=DNA repair protein XRCC1; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
benzene toxicity Zhang, Z. et al. 2004, [Relation of genetic polymorphism of XRCC1 with risks of chronic benzene poisoning], Wei sheng yan jiu. 2004 Sep;33(5):521-7.
[PubMed 15612468]
The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase.
benzene toxicity Huang, H. L. et al. 2007, Association between genetic polymorphisms of DNA repair genes XRCC1, XRCC3 and susceptibility to chronic benzene poisoning., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2007 25(4) 193-6.
[PubMed 17535647]
Subjects with XRCC3 18067T variant allele are tolerance sub-group to benzene poisoning. Patients carrying XRCC1 27466 G/G genotype develop chronic benzene poisoning later.
benzene toxicity Xu, J. N. et al. 2007, Analysis for the association between genetic polymorphisms of XRCC1, XPD, XRCC3, CCND1 and the latency of the occupational chronic benzene poisoning, Zhonghua Yu Fang Yi Xue Za Zhi 2007 41(2) 114-7.
[PubMed 17605237]
The polymorphisms of XRCC1 and CCND1 potentially modify the latency of the chronic benzene poisoning among workers exposed to benzene.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on F5H8D7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.