Human Gene EGR4 (uc010yrk.1)
Description: Homo sapiens early growth response 4 (EGR4), mRNA.
Transcript (Including UTRs)
Position: hg19 chr2:73,518,487-73,520,829 Size: 2,343 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr2:73,518,585-73,520,754 Size: 2,170 Coding Exon Count: 2
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): EGR4
CDC HuGE Published Literature: EGR4
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D015058
1-Naphthylisothiocyanate
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
C030370
2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
D000643
Ammonium Chloride
D017638
Asbestos, Crocidolite
D001241
Aspirin
D019327
Copper Sulfate
D005473
Fluoxetine
D006861
Hydrogen Peroxide
more ... click here to view the complete list
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
Pfam Domains: PF00096 - Zinc finger, C2H2 type
SCOP Domains: 57667 - C2H2 and C2HC zinc fingers
ModBase Predicted Comparative 3D Structure on G3V1T5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
LF207249 - JP 2014500723-A/14752: Polycomb-Associated Non-Coding RNAs.X60104 - H.sapiens mRNA for zinc finger protein.BC136252 - Homo sapiens early growth response 4, mRNA (cDNA clone MGC:167862 IMAGE:9020239), complete cds.BC143379 - Homo sapiens early growth response 4, mRNA (cDNA clone MGC:176902 IMAGE:9051885), complete cds.LF212057 - JP 2014500723-A/19560: Polycomb-Associated Non-Coding RNAs.JD129879 - Sequence 110903 from Patent EP1572962.JD395679 - Sequence 376703 from Patent EP1572962.JD274467 - Sequence 255491 from Patent EP1572962.AK314154 - Homo sapiens cDNA, FLJ94860, highly similar to Homo sapiens early growth response 4 (EGR4), mRNA.AB463596 - Synthetic construct DNA, clone: pF1KB9734, Homo sapiens EGR4 gene for early growth response 4, without stop codon, in Flexi system.BC034462 - Homo sapiens, clone IMAGE:5179180, mRNA.LF213053 - JP 2014500723-A/20556: Polycomb-Associated Non-Coding RNAs.JD123181 - Sequence 104205 from Patent EP1572962.JD405661 - Sequence 386685 from Patent EP1572962.JD190330 - Sequence 171354 from Patent EP1572962.JD538234 - Sequence 519258 from Patent EP1572962.JD081310 - Sequence 62334 from Patent EP1572962.JD391598 - Sequence 372622 from Patent EP1572962.MA442826 - JP 2018138019-A/14752: Polycomb-Associated Non-Coding RNAs.MA447634 - JP 2018138019-A/19560: Polycomb-Associated Non-Coding RNAs.MA448630 - JP 2018138019-A/20556: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: BC143379, G3V1T5, G3V1T5_HUMAN, hCG_40551, NM_001965, NP_001956UCSC ID: uc010yrk.1RefSeq Accession: NM_001965
Protein: G3V1T5
CCDS: CCDS1925.2
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
BC143379.1
exon count:
2 CDS single in 3' UTR:
no
RNA size:
1643
ORF size:
1767 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3711.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.