Description: Homo sapiens neuronal PAS domain protein 2 (NPAS2), mRNA. RefSeq Summary (NM_002518): The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:101,437,487-101,613,287 Size: 175,801 Total Exon Count: 21 Strand: + Coding Region Position: hg19 chr2:101,437,489-101,612,044 Size: 174,556 Coding Exon Count: 21
ID:F5H027_HUMAN DESCRIPTION: SubName: Full=Neuronal PAS domain-containing protein 2; SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. SIMILARITY: Contains 2 PAS (PER-ARNT-SIM) domains. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
autism Nicholas, B. et al. 2007, Association of Per1 and Npas2 with autistic disorder, Mol Psychiatry 2007.
[PubMed 17264841]
Cholesterol Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903299]
Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on F5H027
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ897259 - Synthetic construct Homo sapiens clone ccsbBroadEn_06653 NPAS2 gene, encodes complete protein. U77970 - Human neuronal PAS2 (NPAS2) mRNA, complete cds. BC072383 - Homo sapiens neuronal PAS domain protein 2, mRNA (cDNA clone MGC:71151 IMAGE:6371187), complete cds. BC051351 - Homo sapiens neuronal PAS domain protein 2, mRNA (cDNA clone MGC:59643 IMAGE:6538324), complete cds. AK294733 - Homo sapiens cDNA FLJ59682 complete cds, highly similar to Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4). BC028107 - Homo sapiens neuronal PAS domain protein 2, mRNA (cDNA clone IMAGE:5248433), partial cds. U51625 - Human MOP4 mRNA, partial cds. KJ534892 - Homo sapiens clone NPAS2_iso-A_adult-A01 neuronal PAS domain protein 2 isoform A (NPAS2) mRNA, partial cds, alternatively spliced. AK226093 - Homo sapiens mRNA for neuronal PAS domain protein 2 variant, clone: ef04754. BX640699 - Homo sapiens mRNA; cDNA DKFZp686F0725 (from clone DKFZp686F0725). AK095806 - Homo sapiens cDNA FLJ38487 fis, clone FEBRA2023377, highly similar to NEURONAL PAS DOMAIN PROTEIN 2. JD035213 - Sequence 16237 from Patent EP1572962. AK128586 - Homo sapiens cDNA FLJ46745 fis, clone TRACH3021883, moderately similar to Neuronal PAS domain protein 2. AK091939 - Homo sapiens cDNA FLJ34620 fis, clone KIDNE2014789, highly similar to NEURONAL PAS DOMAIN PROTEIN 2. AK091665 - Homo sapiens cDNA FLJ34346 fis, clone FEBRA2010768. AK026791 - Homo sapiens cDNA: FLJ23138 fis, clone LNG08913. JD132305 - Sequence 113329 from Patent EP1572962. JD408026 - Sequence 389050 from Patent EP1572962. JD050197 - Sequence 31221 from Patent EP1572962. JD435213 - Sequence 416237 from Patent EP1572962. JD036892 - Sequence 17916 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04710 - Circadian rhythm - mammal