Human Gene IL1RL1 (uc010ywa.2)
  Description: Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), transcript variant 2, mRNA.
RefSeq Summary (NM_003856): The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr2:102,927,962-102,961,182 Size: 33,221 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr2:102,956,637-102,959,892 Size: 3,256 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:102,927,962-102,961,182)mRNA (may differ from genome)Protein (211 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): IL1RL1
CDC HuGE Published Literature: IL1RL1
Positive Disease Associations: Asthma , Celiac disease , Eosinophils , plasma eosinophil count
Related Studies:
  1. Asthma
    Dara G Torgerson et al. Nature genetics 2011, Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations., Nature genetics. [PubMed 21804549]
  2. Celiac disease
    Hunt ,et al. 2008, Newly identified genetic risk variants for celiac disease related to the immune response, Nature genetics 2008 40- 4 : 395-402. [PubMed 18311140]
  3. Celiac disease
    Dubois ,et al. Nat Genet 2010, Multiple common variants for celiac disease influencing immune gene expression , Nature genetics 2010 42- 4 : 295-302. [PubMed 20190752]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 52.07 RPKM in Lung
Total median expression: 153.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.71268-0.238 Picture PostScript Text
3' UTR -356.241290-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR015621 - IL1-receptor_fam
IPR004074 - IL1_rcpt_I/II

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on B4E0I3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AB012701 - Homo sapiens mRNA for ST2L, 5' noncoding region including distal exon (exon 1a), complete cds.
AK313967 - Homo sapiens cDNA, FLJ94614, Homo sapiens interleukin 18 receptor 1 (IL18R1), mRNA.
AK303389 - Homo sapiens cDNA FLJ57760 complete cds, highly similar to Interleukin-1 receptor-like 1 precursor.
JD102381 - Sequence 83405 from Patent EP1572962.
JD328377 - Sequence 309401 from Patent EP1572962.
BC012580 - Homo sapiens interleukin 1 receptor-like 1, mRNA (cDNA clone IMAGE:4043930), with apparent retained intron.
BC030975 - Homo sapiens interleukin 1 receptor-like 1, mRNA (cDNA clone MGC:32623 IMAGE:4770131), complete cds.
LF383602 - JP 2014500723-A/191105: Polycomb-Associated Non-Coding RNAs.
AK291578 - Homo sapiens cDNA FLJ77458 complete cds, highly similar to Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), transcript variant 2, mRNA.
AB029084 - Homo sapiens ST2V mRNA, complete cds.
D12763 - Homo sapiens mRNA for ST2 protein.
E07716 - cDNA encoding human ST2.
KJ892704 - Synthetic construct Homo sapiens clone ccsbBroadEn_02098 IL1RL1 gene, encodes complete protein.
CU689060 - Synthetic construct Homo sapiens gateway clone IMAGE:100022208 5' read IL1RL1 mRNA.
AB587480 - Synthetic construct DNA, clone: pF1KB8639, Homo sapiens IL1RL1 gene for interleukin 1 receptor-like 1, without stop codon, in Flexi system.
AM392936 - Synthetic construct Homo sapiens clone IMAGE:100002717 for hypothetical protein (IL1RL1 gene).
LF317521 - JP 2014500723-A/125024: Polycomb-Associated Non-Coding RNAs.
LF317522 - JP 2014500723-A/125025: Polycomb-Associated Non-Coding RNAs.
LF317523 - JP 2014500723-A/125026: Polycomb-Associated Non-Coding RNAs.
LF317524 - JP 2014500723-A/125027: Polycomb-Associated Non-Coding RNAs.
LF317525 - JP 2014500723-A/125028: Polycomb-Associated Non-Coding RNAs.
JD301838 - Sequence 282862 from Patent EP1572962.
JD236624 - Sequence 217648 from Patent EP1572962.
LF317526 - JP 2014500723-A/125029: Polycomb-Associated Non-Coding RNAs.
JD109596 - Sequence 90620 from Patent EP1572962.
EU181431 - Homo sapiens interleukin 1 receptor-like 1 isoform 2 (IL1RL1) mRNA, partial cds, alternatively spliced.
LF317527 - JP 2014500723-A/125030: Polycomb-Associated Non-Coding RNAs.
JD224562 - Sequence 205586 from Patent EP1572962.
LF317528 - JP 2014500723-A/125031: Polycomb-Associated Non-Coding RNAs.
JD380544 - Sequence 361568 from Patent EP1572962.
JD437505 - Sequence 418529 from Patent EP1572962.
JD551092 - Sequence 532116 from Patent EP1572962.
JD561993 - Sequence 543017 from Patent EP1572962.
JD145489 - Sequence 126513 from Patent EP1572962.
JD510759 - Sequence 491783 from Patent EP1572962.
JD509167 - Sequence 490191 from Patent EP1572962.
MA265539 - JP 2017503859-A/81: Materials and methods for modulation of tendon healing.
JD509884 - Sequence 490908 from Patent EP1572962.
JD092708 - Sequence 73732 from Patent EP1572962.
JD483747 - Sequence 464771 from Patent EP1572962.
JD286130 - Sequence 267154 from Patent EP1572962.
JD170276 - Sequence 151300 from Patent EP1572962.
MA265540 - JP 2017503859-A/82: Materials and methods for modulation of tendon healing.
JD120383 - Sequence 101407 from Patent EP1572962.
JD110195 - Sequence 91219 from Patent EP1572962.
JD112593 - Sequence 93617 from Patent EP1572962.
JD491339 - Sequence 472363 from Patent EP1572962.
AL117622 - Homo sapiens mRNA; cDNA DKFZp564N1164 (from clone DKFZp564N1164).
JD108342 - Sequence 89366 from Patent EP1572962.
JD350575 - Sequence 331599 from Patent EP1572962.
MA619179 - JP 2018138019-A/191105: Polycomb-Associated Non-Coding RNAs.
MA553098 - JP 2018138019-A/125024: Polycomb-Associated Non-Coding RNAs.
MA553099 - JP 2018138019-A/125025: Polycomb-Associated Non-Coding RNAs.
MA553100 - JP 2018138019-A/125026: Polycomb-Associated Non-Coding RNAs.
MA553101 - JP 2018138019-A/125027: Polycomb-Associated Non-Coding RNAs.
MA553102 - JP 2018138019-A/125028: Polycomb-Associated Non-Coding RNAs.
MA553103 - JP 2018138019-A/125029: Polycomb-Associated Non-Coding RNAs.
MA553104 - JP 2018138019-A/125030: Polycomb-Associated Non-Coding RNAs.
MA553105 - JP 2018138019-A/125031: Polycomb-Associated Non-Coding RNAs.
MA886701 - WO 2019045075-A/2: A Therapeutic Agent for Endometriosis comprising IL-33 Antagonist.

-  Other Names for This Gene
  Alternate Gene Symbols: AK303389, B4E0I3, B4E0I3_HUMAN, NM_003856, NP_003847
UCSC ID: uc010ywa.2
RefSeq Accession: NM_003856
Protein: B4E0I3

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK303389.1
exon count: 7CDS single in 3' UTR: no RNA size: 898
ORF size: 636CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1307.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 1307# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.