Description: Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), transcript variant 2, mRNA. RefSeq Summary (NM_003856): The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:102,927,962-102,961,182 Size: 33,221 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr2:102,956,637-102,959,892 Size: 3,256 Coding Exon Count: 5
Asthma Dara G Torgerson et al. Nature genetics 2011, Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations., Nature genetics.
[PubMed 21804549]
Celiac disease Hunt ,et al. 2008, Newly identified genetic risk variants for celiac disease related to the immune response, Nature genetics 2008 40- 4 : 395-402.
[PubMed 18311140]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B4E0I3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.