Description: Homo sapiens taspase, threonine aspartase, 1 (TASP1), mRNA. RefSeq Summary (NM_017714): This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr20:13,463,874-13,619,583 Size: 155,710 Total Exon Count: 11 Strand: -
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK299940 - Homo sapiens cDNA FLJ50393 complete cds, moderately similar to Threonine aspartase 1 (EC 3.4.25.-). AK000219 - Homo sapiens cDNA FLJ20212 fis, clone COLF1860. AK025671 - Homo sapiens cDNA: FLJ22018 fis, clone HEP07914. BC025266 - Homo sapiens taspase, threonine aspartase, 1, mRNA (cDNA clone MGC:39159 IMAGE:3929609), complete cds. AK304488 - Homo sapiens cDNA FLJ52055 complete cds, moderately similar to Threonine aspartase 1 (EC 3.4.25.-). AK316311 - Homo sapiens cDNA, FLJ79210 complete cds, moderately similar to Threonine aspartase 1 (EC 3.4.25.-).