Human Gene CCT8 (uc011acp.2)
  Description: Homo sapiens chaperonin containing TCP1, subunit 8 (theta) (CCT8), mRNA.
RefSeq Summary (NM_006585): This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013].
Transcript (Including UTRs)
   Position: hg19 chr21:30,428,648-30,445,672 Size: 17,025 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr21:30,428,796-30,444,275 Size: 15,480 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:30,428,648-30,445,672)mRNA (may differ from genome)Protein (529 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: B4DEM7_HUMAN
DESCRIPTION: SubName: Full=T-complex protein 1 subunit theta; SubName: Full=cDNA FLJ53379, highly similar to T-complex protein 1 subunit theta;
SIMILARITY: Belongs to the TCP-1 chaperonin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 152.00 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2009.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.10126-0.334 Picture PostScript Text
3' UTR -24.30148-0.164 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012721 - Chap_CCT_theta
IPR017998 - Chaperone_TCP-1
IPR002194 - Chaperonin_TCP-1_CS
IPR002423 - Cpn60/TCP-1

Pfam Domains:
PF00118 - TCP-1/cpn60 chaperonin family

SCOP Domains:
48592 - GroEL equatorial domain-like
52029 - GroEL apical domain-like
54849 - GroEL-intermediate domain like

ModBase Predicted Comparative 3D Structure on B4DEM7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF210654 - JP 2014500723-A/18157: Polycomb-Associated Non-Coding RNAs.
BC035472 - Homo sapiens chaperonin containing TCP1, subunit 8 (theta), mRNA (cDNA clone IMAGE:3918102).
AK222490 - Homo sapiens mRNA for chaperonin containing TCP1, subunit 8 (theta) variant, clone: adKA03147.
BC012584 - Homo sapiens chaperonin containing TCP1, subunit 8 (theta), mRNA (cDNA clone MGC:13491 IMAGE:4133182), complete cds.
BC095470 - Homo sapiens chaperonin containing TCP1, subunit 8 (theta), mRNA (cDNA clone MGC:111375 IMAGE:30523886), complete cds.
BC072001 - Homo sapiens chaperonin containing TCP1, subunit 8 (theta), mRNA (cDNA clone MGC:88704 IMAGE:6298609), complete cds.
AK293705 - Homo sapiens cDNA FLJ53379 complete cds, highly similar to T-complex protein 1 subunit theta.
D13627 - Homo sapiens KIAA0002 mRNA.
AK308063 - Homo sapiens cDNA, FLJ98011.
AK298801 - Homo sapiens cDNA FLJ59382 complete cds, highly similar to T-complex protein 1 subunit theta.
LF339804 - JP 2014500723-A/147307: Polycomb-Associated Non-Coding RNAs.
AB590043 - Synthetic construct DNA, clone: pFN21AA0002, Homo sapiens CCT8 gene for chaperonin containing TCP1, subunit 8, without stop codon, in Flexi system.
LF339805 - JP 2014500723-A/147308: Polycomb-Associated Non-Coding RNAs.
LF339807 - JP 2014500723-A/147310: Polycomb-Associated Non-Coding RNAs.
LF339808 - JP 2014500723-A/147311: Polycomb-Associated Non-Coding RNAs.
LF339809 - JP 2014500723-A/147312: Polycomb-Associated Non-Coding RNAs.
LF339810 - JP 2014500723-A/147313: Polycomb-Associated Non-Coding RNAs.
LF339811 - JP 2014500723-A/147314: Polycomb-Associated Non-Coding RNAs.
LF339813 - JP 2014500723-A/147316: Polycomb-Associated Non-Coding RNAs.
LF339816 - JP 2014500723-A/147319: Polycomb-Associated Non-Coding RNAs.
LF339817 - JP 2014500723-A/147320: Polycomb-Associated Non-Coding RNAs.
LF339819 - JP 2014500723-A/147322: Polycomb-Associated Non-Coding RNAs.
LF339820 - JP 2014500723-A/147323: Polycomb-Associated Non-Coding RNAs.
LF339821 - JP 2014500723-A/147324: Polycomb-Associated Non-Coding RNAs.
LF339822 - JP 2014500723-A/147325: Polycomb-Associated Non-Coding RNAs.
Z37163 - H.sapiens mRNA for homologue of the mouse Cctq gene.
BC005220 - Homo sapiens chaperonin containing TCP1, subunit 8 (theta), mRNA (cDNA clone IMAGE:3930332).
MA446231 - JP 2018138019-A/18157: Polycomb-Associated Non-Coding RNAs.
MA575381 - JP 2018138019-A/147307: Polycomb-Associated Non-Coding RNAs.
MA575382 - JP 2018138019-A/147308: Polycomb-Associated Non-Coding RNAs.
MA575384 - JP 2018138019-A/147310: Polycomb-Associated Non-Coding RNAs.
MA575385 - JP 2018138019-A/147311: Polycomb-Associated Non-Coding RNAs.
MA575386 - JP 2018138019-A/147312: Polycomb-Associated Non-Coding RNAs.
MA575387 - JP 2018138019-A/147313: Polycomb-Associated Non-Coding RNAs.
MA575388 - JP 2018138019-A/147314: Polycomb-Associated Non-Coding RNAs.
MA575390 - JP 2018138019-A/147316: Polycomb-Associated Non-Coding RNAs.
MA575393 - JP 2018138019-A/147319: Polycomb-Associated Non-Coding RNAs.
MA575394 - JP 2018138019-A/147320: Polycomb-Associated Non-Coding RNAs.
MA575396 - JP 2018138019-A/147322: Polycomb-Associated Non-Coding RNAs.
MA575397 - JP 2018138019-A/147323: Polycomb-Associated Non-Coding RNAs.
MA575398 - JP 2018138019-A/147324: Polycomb-Associated Non-Coding RNAs.
MA575399 - JP 2018138019-A/147325: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK293705, B4DEM7, B4DEM7_HUMAN, NM_006585, NP_006576
UCSC ID: uc011acp.2
RefSeq Accession: NM_006585
Protein: B4DEM7 CCDS: CCDS33528.1, CCDS68181.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK293705.1
exon count: 16CDS single in 3' UTR: no RNA size: 1862
ORF size: 1590CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 3377.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.